Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Alimemazine: Difference between pages

{{Short description|Chemical compound}}

| Watchedfields = changed

| verifiedrevid = 477317349

| alt =

| alt2 =

| USAN=trimeprazine

| BAN=trimeprazine

<!-- Clinical data -->

| DailyMedID = Trimeprazine

| MedlinePlus =

| routes_of_administration = [[By mouth]]

| class = [[Anti-allergic agent]]

| ATC_prefix = R06

| ATC_suffix = AD01

| ATC_supplemental =

| legal_UK = POM

| legal_US = Rx-only

| legal_US_comment = <ref>{{cite web | title=Trimeprazine tartrate powder | website=DailyMed | date=14 March 2019 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=44b6cea3-21d4-4164-830b-91fa1fab6510 | access-date=15 July 2024}}</ref>

<!-- Pharmacokinetic data -->

| metabolism = [[Liver]]

| elimination_half-life = 4.78 ± 0.59 hours<ref name="pmid2871150">{{cite journal | vauthors = Hu OY, Gfeller E, Perrin JH, Curry SH | title = Relative bioavailability of trimeprazine tablets investigated in man using HPLC with electrochemical detection | journal = The Journal of Pharmacy and Pharmacology | volume = 38 | issue = 3 | pages = 172–6 |date=March 1986 | pmid = 2871150 | doi = 10.1111/j.2042-7158.1986.tb04539.x| s2cid = 506087 }}</ref>

<!-- Identifiers -->

| IUPHAR_ligand = 7237

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| UNII2 = 362NW1LD6Z

| KEGG2 = D02245

| synonyms = trimeprazine

<!-- Chemical data -->

| IUPAC_name = ''N'',''N'',2-trimethyl-3-phenothiazin-10-yl-propan-1-amine

| C=18 | H=22 | N=2 | S=1

'''Alimemazine''' ([[International Nonproprietary Name|INN]]), also known as '''trimeprazine''', commonly provided as a [[tartrate]] salt, is a [[phenothiazine]] derivative that is used as an [[antipruritic]] (it prevents itching from causes such as [[eczema]] or [[poison ivy]], by acting as an [[antihistamine]]).<ref>{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/78032|title=(3R,4R)-3,4-dihydroxyhexane-2,5-dione;N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine|website=pubchem.ncbi.nlm.nih.gov}}</ref> It also acts as a [[sedative]], [[hypnotic]], and [[antiemetic]] for prevention of [[motion sickness]]. Although it is structurally related to drugs such as [[chlorpromazine]], it is not used as an [[antipsychotic]].<ref>{{cite web|url=http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00258.txt|title=Drugbank:Trimeprazine|access-date=2007-09-15|archive-date=2006-12-30|archive-url=https://web.archive.org/web/20061230231431/http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00258.txt|url-status=dead}}</ref> In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including [[generalized anxiety disorder|GAD]]), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, [[somatoform disorder|somatoform]] [[dysautonomia|autonomic dysfunction]] and various [[neurosis|neuroses]].<ref>{{Cite web|url=https://www.rlsnet.ru/drugs/teralidzen-32413|title=Тералиджен — инструкция по применению, дозы, побочные действия, описание препарата: таблетки, покрытые пленочной оболочкой,раствор для внутримышечного введения, 5 мг/мл, 5 мг|website=РЛС®}}</ref>

Alimemazine is not approved for use in humans in the United States. The combination of alimemazine and [[prednisolone]] (commonly sold under the brand name Temaril-P) is licensed as an antipruritic and [[antitussive]] in dogs.<ref>{{cite web | title=Temaril-P- trimeprazine tartrate and prednisolone tablet | website=DailyMed | date=12 January 2023 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9de07d0d-44df-47da-b4b7-24f5fc803b46 | access-date=15 July 2024}}</ref> A [[generic medication|generic]] version of the combination [[trimeprazine/prednisolone]] was approved by the US [[Food and Drug Administration]] (FDA) in June 2024.<ref>{{cite web | title=FDA Roundup: June 21, 2024 | website=U.S. [[Food and Drug Administration]] (FDA) | date=21 June 2024 | url=https://www.fda.gov/news-events/press-announcements/fda-roundup-june-21-2024 | access-date=15 July 2024}}</ref><ref>{{cite web |title=FOI Summary for the Original Approval of ANADA 200-784 |url=https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15546 |publisher=United States Food and Drug Administration |access-date=29 September 2024 |archive-url=https://web.archive.org/web/20240715034254/https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15546 |archive-date=15 July 2024 |language=en |url-status=live}}</ref>

== Society and culture ==

=== Brand names ===

Brand names include Nedeltran, Panectyl, Repeltin, Teraligen, Therafene, Theraligene, Theralen, Thegalin, Theralene, Vallergan, Vanectyl, and Temaril.

== References ==

{{Reflist}}

{{Antihistamines}}

{{Cholinergics}}

{{Histaminergics}}

{{Tricyclics}}

[[Category:Antiemetics]]

[[Category:Phenothiazines]]

[[Category:H1 receptor antagonists]]