Amidorphin: Difference between revisions

| verifiedrevid = 446609792

| ImageFile = Amidorphin.png

| Section1 = {{Chembox Identifiers

| CASNo = 94885-44-6

| PubChem = 16132380

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| InChI = InChI=1S/C131H200N30O43S2/c1-66(2)54-88(110(136)183)153-130(203)109(70(9)10)159-122(195)80(35-41-101(169)170)142-99(167)64-137-98(166)63-140-113(186)92(60-96(135)164)154-111(184)71(11)141-114(187)81(36-42-102(171)172)146-117(190)82(37-43-103(173)174)147-118(191)84(39-45-105(177)178)152-129(202)108(69(7)8)160-123(196)85(40-46-106(179)180)149-124(197)90(56-68(5)6)157-128(201)95-26-21-51-161(95)131(204)94(59-74-29-33-76(163)34-30-74)158-125(198)89(55-67(3)4)155-119(192)83(38-44-104(175)176)148-127(200)93(61-107(181)182)156-121(194)87(48-53-206-13)150-116(189)79(25-18-20-50-133)144-115(188)78(24-17-19-49-132)145-120(193)86(47-52-205-12)151-126(199)91(58-72-22-15-14-16-23-72)143-100(168)65-138-97(165)62-139-112(185)77(134)57-73-27-31-75(162)32-28-73/h14-16,22-23,27-34,66-71,77-95,108-109,162-163H,17-21,24-26,35-65,132-134H2,1-13H3,(H2,135,164)(H2,136,183)(H,137,166)(H,138,165)(H,139,185)(H,140,186)(H,141,187)(H,142,167)(H,143,168)(H,144,188)(H,145,193)(H,146,190)(H,147,191)(H,148,200)(H,149,197)(H,150,189)(H,151,199)(H,152,202)(H,153,203)(H,154,184)(H,155,192)(H,156,194)(H,157,201)(H,158,198)(H,159,195)(H,160,196)(H,169,170)(H,171,172)(H,173,174)(H,175,176)(H,177,178)(H,179,180)(H,181,182)/t71-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,108-,109-/m0/s1

| Section2 = {{Chembox Properties

| Formula = C₁₃₁H₂₀₀N₃₀O₄₃S₂

| MolarMass = 2947.29 g/mol

| Appearance =

| Density =

| MeltingPt =

| BoilingPt =

| Solubility =

| Section3 = {{Chembox Hazards

| MainHazards =

| FlashPt =

| Autoignition =

'''Amidorphin''' is an [[endogenous]], [[C-terminus|C-terminally]] [[amide|amidated]], [[opioid]] [[peptide]] generated as a [[cleavage|cleavage product]] of [[proenkephalin A]] that is widely distributed in the [[mammalian]] [[brain]], with particularly high concentrations found in the [[adrenal medulla]], [[posterior pituitary]], and [[striatum]].<ref name="pmid3965972">{{cite journal | author = Seizinger BR | title = Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla | journal = Nature | volume = 313 | issue = 5997 | pages = 57–9 | year = 1985 | pmid = 3965972 | doi =10.1038/313057a0 | url = | author-separator = , | author2 = Liebisch DC | author3 = Gramsch C | display-authors = 3 | last4 = Herz | first4 = A | last5 = Weber | first5 = E | last6 = Evans | first6 = CJ | last7 = Esch | first7 = FS | last8 = Böhlen | first8 = P }}</ref><ref name="pmid4045460">{{cite journal | author = Liebisch DC, Seizinger BR, Michael G, Herz A | title = Novel opioid peptide amidorphin: characterization and distribution of amidorphin-like immunoreactivity in bovine, ovine, and porcine brain, pituitary, and adrenal medulla | journal = Journal of Neurochemistry | volume = 45 | issue = 5 | pages = 1495–503 | year = 1985 | month = November | pmid = 4045460 | doi = | url = }}</ref> In some brain areas, amidorphin is extensively further reduced into smaller fragments, such as the non-opioid peptide [[amidorphin-(8-26)]] which lacks the [[N-terminus|''N''-terminal]] [[Met-enkephalin|[Met]enkephalin]] [[peptide sequence|sequence]] of amidorphin; accordingly, [Met]enkephalin may also be a cleavage product of amidorphin.<ref name="pmid3456613">{{cite journal | author = Liebisch DC, Weber E, Kosicka B, Gramsch C, Herz A, Seizinger BR | title = Isolation and structure of a C-terminally amidated nonopioid peptide, amidorphin-(8-26), from bovine striatum: a major product of proenkephalin in brain but not in adrenal medulla | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 6 | pages = 1936–40 | year = 1986 | month = March | pmid = 3456613 | pmc = 323199 | doi = 10.1073/pnas.83.6.1936| url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=3456613}}</ref>

== See also ==

== References ==

{{Reflist}}

{{Analgesics}}

{{Opioids}}

[[Category:Opioids]]

[[sr:Amidorfin]]