Benzylpenicilloyl polylysine: Difference between revisions

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Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').
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{{Short description|Chemical compound}}
{{Orphan|date=September 2011}}

{{orphan | date = February 2011}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 417633416
| verifiedrevid = 459813303
| IUPAC_name = [2''S''-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate : <small>L</small>-Lysine homopolymer
| IUPAC_name = [2''S''-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate : <small>L</small>-Lysine homopolymer
| image = Benzylpenicilloyl polylysine (structural diagram).png
| image = Benzylpenicilloyl polylysine (structural diagram).png
| width =
| width =
| alt =
| alt =
| image2 =
| image2 =
| width2 =
| width2 =
⚫
| drug_name =
| imagename = <!-- else may use drug_name -->
⚫
<!-- Clinical data -->
⚫
| drug_name =
⚫
| tradename = Pre-Pen

⚫
<!--Clinical data-->
⚫
| tradename =
| licence_EU = <!-- EMA requires brand name -->
| licence_EU = <!-- EMA requires brand name -->
| licence_US = Pre-Pen
| licence_US = Pre-Pen
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| pregnancy_category =
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_US = Rx-only
| legal_status =
| legal_status =
| dependency_liability =
| dependency_liability =
| routes_of_administration = Liquid intradermal
| routes_of_administration = Liquid intradermal
⚫
<!-- Pharmacokinetic data -->

| bioavailability =
⚫
<!--Pharmacokinetic data-->
| bioavailability =
| protein_bound =
| protein_bound =
| metabolism =
⚫
| elimination_half-life =
| metabolism =
⚫
| excretion =
⚫
| elimination_half-life =
⚫
<!-- Identifiers -->
⚫
| excretion =
⚫
| CAS_number_Ref = {{cascite|changed|??}}

⚫
| CAS_number = 31855-75-1
⚫
<!--Identifiers-->
⚫
| CAS_supplemental =
⚫
| CAS_number_Ref = {{cascite|correct|??}}
⚫
| UNII_Ref = {{fdacite|correct|FDA}}
⚫
| CAS_number = <!-- blanked - oldvalue: 31855-75-1 -->
| UNII = 76479814OY
⚫
| CAS_supplemental =
| ATCvet =
| ATCvet =
| ATC_prefix = <!-- 'none' if uncategorised -->
| ATC_prefix = none
| ATC_suffix =
| ATC_suffix =
| ATC_supplemental =
| ATC_supplemental =
| PubChem =
| PubChem =
| PubChemSubstance =
| PubChemSubstance =
| IUPHAR_ligand =
| IUPHAR_ligand =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank =
| DrugBank = DB00895
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = NA
| ChemSpiderID = none
⚫
| UNII_Ref = {{fdacite|correct|FDA}}
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG_Ref = {{keggcite|correct|kegg}}
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = <!-- blanked - oldvalue: 1201779 -->
| ChEMBL = 1201779
| synonyms = Pre-Pen
| synonyms = Pre-Pen
⚫
<!-- Chemical data -->

| chemical_formula =
⚫
<!--Chemical data-->
| chemical_formula =
| molecular_weight =
⚫
| SMILES =

| molecular_weight =
⚫
| smiles =
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI =
| StdInChI =
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey =
| StdInChIKey =
| density =
| density =
| melting_point =
| melting_point =
| melting_high =
| melting_high =
| melting_notes =
| melting_notes =
| boiling_point =
| boiling_point =
| boiling_notes =
| boiling_notes =
| solubility =
| solubility =
| specific_rotation =
| specific_rotation =
| sec_combustion =
| sec_combustion =
}}
}}


'''Benzylpenicilloyl polylysine''' (Pre-Pen) is used as a skin test before the administration of [[penicillin]]. It is used to detect the [[immunoglobulin]] E [[antibody|antibodies]].<ref>http://www.flexyx.com/P/Pre-pen.html</ref><ref>http://www.pharmgkb.org/do/serve?objId=PA164754810&objCls=Drug</ref><ref>http://www.drugbank.ca/drugs/DB00895</ref> The chemical structure consists of the benzylpenicilloyl group attached to a polymer of <small>L</small>-[[lysine]].<ref>{{cite journal | author = Vemuri, Preeti; Harris, Kathleen E.; Suh, Lydia A.; Grammer, Leslie C. | title = Preparation of benzylpenicilloyl-polylysine: a preliminary study | journal = Allergy and Asthma Proceedings | year = 2004 | volume = 25 | issue = 3 | pages = 165–168}}</ref><ref>{{Cite journal
'''Benzylpenicilloyl polylysine''' (Pre-Pen) is used as a skin test before the administration of [[penicillin]]. It is used to detect the [[immunoglobulin]] E [[antibody|antibodies]].<ref>{{Cite web | title = Benzylpenicilloyl polylysine
| url=http://www.pharmgkb.org/do/serve?objId=PA164754810&objCls=Drug | work = PharmGKB}}</ref><ref>{{Cite web | url=http://www.drugbank.ca/drugs/DB00895 | title=Benzylpenicilloyl polylysine | work = DrugBank }}</ref> The chemical structure consists of the benzylpenicilloyl group attached to a polymer of <small>L</small>-[[lysine]].<ref>{{cite journal | vauthors = Vemuri P, Harris KE, Suh LA, Grammer LC | title = Preparation of benzylpenicilloyl-polylysine: a preliminary study | journal = Allergy and Asthma Proceedings | volume = 25 | issue = 3 | pages = 165–168 | year = 2004 | pmid = 15317320 | name-list-style = vanc }}</ref><ref>{{cite journal | vauthors = Goldschmidt BM, Levine BB | title = The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy | journal = The Journal of Antibiotics | volume = 36 | issue = 6 | pages = 709–714 | date = June 1983 | pmid = 6874593 | doi = 10.7164/antibiotics.36.709 | doi-access = free }}</ref><ref>{{Cite web | url=https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=2fbcc40c-f102-4abe-bce5-a93de95874fe&type=display |title = PRE-PEN® (benzylpenicilloyl polylysine injection USP) Skin Test Antigen | work = DailyMed | publisher = U.S. National Library of Medicine }}</ref>
| pmid = 6874593
| volume = 36
| issue = 6
| pages = 709–14
| last = Goldschmidt
| first = BM
| coauthors = BB Levine
| title = The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy.
| journal = Journal of Antibiotics
| year=1983
}}</ref><ref>http://ainotes.wikispaces.com/file/view/PREPEN_Package_Insert.pdf</ref>


==References==
== References ==
{{reflist}}
{{reflist}}


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