Etrolizumab: Difference between revisions
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Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'CAS_number'). |
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{{Short description|Chemical compound}} |
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{{Drugbox |
{{Drugbox |
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| Verifiedfields = changed |
| Verifiedfields = changed |
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| Watchedfields = changed |
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| verifiedrevid = |
| verifiedrevid = 457121719 |
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| type = mab |
| type = mab |
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| image = |
| image = |
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| mab_type = mab |
| mab_type = mab |
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| source = zu/a |
| source = zu/a |
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| target = integrin |
| target = β7 subunit of α4β7 and αEβ7 integrin heterodimers |
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| tradename = |
| tradename = |
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| Drugs.com = |
| Drugs.com = |
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| pregnancy_US = <!-- A / B / C / D / X --> |
| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category= |
| pregnancy_category= |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> |
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| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> |
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --> |
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --> |
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| elimination_half-life = |
| elimination_half-life = |
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| excretion = |
| excretion = |
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| CAS_number_Ref = {{cascite| |
| CAS_number_Ref = {{cascite|changed|??}} |
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| CAS_number |
| CAS_number = 1044758-60-2 |
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| ATC_prefix = none |
| ATC_prefix = none |
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| ATC_suffix = |
| ATC_suffix = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
| DrugBank = |
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| C=6396 | H=9874 | N=1702 | O=2010 | S=42 |
| IUPHAR_ligand = 8407 | C=6396 | H=9874 | N=1702 | O=2010 | S=42 |
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| molecular_weight = 144.1 kDa |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = |
| ChemSpiderID = none |
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| KEGG_Ref = {{keggcite|changed|kegg}} |
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| KEGG = D09901 |
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}} |
}} |
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'''Etrolizumab''' (rhuMAb Beta7) is a [[biopharmaceutical]] drug candidate being developed for the treatment of [[ulcerative colitis]] and [[Crohn's disease]]. It is a humanized monoclonal antibody against the [[ITGB7|β7 subunit]] of [[integrin]]s α4β7 and αEβ7.<ref>Adis Insight [http://adisinsight.springer.com/drugs/800026082 Etrolizumab] {{Webarchive|url=https://web.archive.org/web/20160603093535/http://adisinsight.springer.com/drugs/800026082 |date=2016-06-03 }} Latest Information Update: 16 Dec 2015</ref> Etrolizumab was developed by [[Genentech]]<ref name=ukmi>UK Medicines Information. [http://www.ukmi.nhs.uk/applications/ndo/record_view_open.asp?newDrugID=6112 etrolizumab at UKMI] {{Webarchive|url=https://web.archive.org/web/20160604005122/http://www.ukmi.nhs.uk/applications/ndo/record_view_open.asp?newDrugID=6112 |date=2016-06-04 }} Page accessed May 10, 2016</ref><ref>{{Cite web|url=https://www.gene.com/medical-professionals/pipeline|title=Genentech: Our Pipeline|website=www.gene.com|access-date=2020-05-22|archive-date=2020-05-24|archive-url=https://web.archive.org/web/20200524223812/https://www.gene.com/medical-professionals/pipeline|url-status=live}}</ref> by engineering the FIB504 antibody to include human IgGl-heavy chain and κ-light chain frameworks; it is manufactured in [[Chinese hamster ovary cell|CHO cells]].<ref>{{cite patent | country = WO | number = 2012135589 | title = Methods of administering beta7 integrin antagonists | assign1 = Genentech and Roche}} For the FIB504 mAb, see Andrew DP et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. {{cite journal | vauthors = Andrew DP, Berlin C, Honda S, Yoshino T, Hamann A, Holzmann B, Kilshaw PJ, Butcher EC | title = Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation | journal = Journal of Immunology | volume = 153 | issue = 9 | pages = 3847–61 | date = November 1994 | doi = 10.4049/jimmunol.153.9.3847 | pmid = 7523506 | s2cid = 32434092 }} as referenced in paragraph 146 of the PCT application.</ref> |
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'''Etrolizumab''' is a humanized monoclonal antibody designed for the treatment of [[inflammatory bowel disease]].<ref>{{cite web|title=Statement On A Nonproprietary Name Adopted By The USAN Council: Etrolizumab|publisher=[[American Medical Association]]|url=http://www.ama-assn.org/resources/doc/usan/etrolizumab.pdf}}</ref> |
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As of 2016, it was in phase III studies for induction and maintenance therapy in people with ulcerative colitis and Crohn's.<ref name=ukmi/><ref name="pmid26914639">{{cite journal | vauthors = Makker J, Hommes DW | title = Etrolizumab for ulcerative colitis: the new kid on the block? | journal = Expert Opinion on Biological Therapy | volume = 16 | issue = 4 | pages = 567–72 | date = 2016 | pmid = 26914639 | doi = 10.1517/14712598.2016.1158807 | s2cid = 24706213 }}</ref><ref name="pmid26630451">{{cite journal | vauthors = Rosenfeld G, Parker CE, MacDonald JK, Bressler B | title = Etrolizumab for induction of remission in ulcerative colitis | journal = The Cochrane Database of Systematic Reviews | issue = 12 | pages = CD011661 | date = December 2015 | volume = 2015 | pmid = 26630451 | doi = 10.1002/14651858.CD011661.pub2 | pmc = 8612697 }}</ref> According to data of one meta-analysis efficacy of Etrolizumab is comparable with conventional therapies such as Infliximab with less adverse events.<ref name="pmid30395950">{{cite journal | vauthors = Motaghi E, Ghasemi-Pirbaluti M, Zabihi M | title = Etrolizumab versus infliximab in the treatment of induction phase of ulcerative colitis: A systematic review and indirect comparison|url=https://www.researchgate.net/publication/328722610 | journal = Pharmacological Research | volume = 139 | pages = 120–125 | date = January 2019 | pmid = 30395950 | doi = 10.1016/j.phrs.2018.11.003 | s2cid = 53235342 }}</ref> |
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Etrolizumab was developed by [[Genentech]]. |
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Phase III clinical trials produced mixed results; and, on October 14, 2020, [[Hoffmann-La Roche]], the parent company of [[Genentech]], abandoned further efforts to develop etrolizumab for [[ulcerative colitis]], but continued development for [[Crohn's disease]],<ref>{{cite journal |last1=Tong |first1=Amber |title=Roche writes off ulcerative colitis portion of etrolizumab program, days after dissecting PhIII setback |journal=Endpoints |date=October 15, 2020 |url=https://endpts.com/roche-writes-off-ulcerative-colitis-portion-of-etrolizumab-program-days-after-dissecting-phiii-setback |access-date=2 January 2021 |archive-date=24 November 2020 |archive-url=https://web.archive.org/web/20201124012928/https://endpts.com/roche-writes-off-ulcerative-colitis-portion-of-etrolizumab-program-days-after-dissecting-phiii-setback/ |url-status=live }}</ref> until disappointing trial results led to this being abandoned too in February 2022.<ref>{{cite web |url=https://www.fiercebiotech.com/biotech/roche-lets-go-etro-dumping-phase-3-crohn-s-prospect-18-months-after-posting-weak-colitis |website=Fierce Biotech |access-date=8 March 2023 |title=Archived copy |archive-date=8 March 2023 |archive-url=https://web.archive.org/web/20230308012715/https://www.fiercebiotech.com/biotech/roche-lets-go-etro-dumping-phase-3-crohn-s-prospect-18-months-after-posting-weak-colitis |url-status=live }}</ref> |
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== References == |
== References == |
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{{Reflist}} |
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<references/> |
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{{monoclonals for immune system}} |
{{monoclonals for immune system}} |
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[[Category:Monoclonal antibodies]] |
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