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Motexafin lutetium: Difference between revisions

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{{chembox
{{chembox
| verifiedrevid = 449584968
| verifiedrevid = 455343846
|ImageFile=Motexafin lutetium.png
| ImageFile=Motexafin lutetium.svg
|ImageSize=200px
| ImageSize=200px
|IUPACName=
| IUPACName=
|OtherNames=Antrin; Lu texaphyrin; Lu-Tex; Lutetium texaphyrin; Lutrin; Optrin; PCI 0123
| OtherNames=Antrin; Lu texaphyrin; Lu-Tex; Lutetium texaphyrin; Lutrin; Optrin; PCI 0123
|Section1={{Chembox Identifiers
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=246252-04-0
| CASNo=246252-04-0
⚫
| PubChem=3081907
| UNII_Ref = {{fdacite|correct|FDA}}
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| SMILES=CC([O-])=O.CCC1=C2[N-]C(/C=C3N=C(/C=N/C4=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C4/N=C/C(C(C)=C/5CCCO)=[N]([Lu+3])C5=C/2)C(C)=C\3CCCO)=C1CC
| UNII = 0V38NF6N89
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| PubChem=3081907
⚫
| SMILES=CC([O-])=O.CCC1=C2[N-]C(/C=C3N=C(/C=N/C4=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C4/N=C/C(C(C)=C/5CCCO)=[N]([Lu+3])C5=C/2)C(C)=C\3CCCO)=C1CC
}}
}}
|Section2={{Chembox Properties
|Section2={{Chembox Properties
| C=52 | H=72 | Lu=1 | N=5 | O=14
| C=52 | H=72 | Lu=1 | N=5 | O=14
| Appearance=
| Appearance=
| Density=
| Density=
| MeltingPt=
| MeltingPt=
| BoilingPt=
| BoilingPt=
| Solubility=
| Solubility=
}}
}}
|Section3={{Chembox Hazards
|Section3={{Chembox Hazards
| MainHazards=
| MainHazards=
| FlashPt=
| FlashPt=
| AutoignitionPt =
| Autoignition=
}}
}}
}}
}}
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It is a photosensitiser for use in [[photodynamic therapy]] to treat skin conditions and superficial cancers.
It is a photosensitiser for use in [[photodynamic therapy]] to treat skin conditions and superficial cancers.


It has also been tested for use in [[photoangioplasty]] (photodynamic treatment of diseased arteries).<ref>[http://www2.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/09-25-2002/0001806282&EDATE= Pharmacyclics Announces Final Phase 1 Results of Antrin Phototherapy For Coronary Artery Disease], 2002</ref>
It has also been tested for use in [[photoangioplasty]] (photodynamic treatment of diseased arteries).<ref>[http://www2.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/09-25-2002/0001806282&EDATE= Pharmacyclics Announces Final Phase 1 Results of Antrin Phototherapy For Coronary Artery Disease] {{webarchive|url=https://web.archive.org/web/20110716075826/http://www2.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=%2Fwww%2Fstory%2F09-25-2002%2F0001806282&EDATE= |date=2011-07-16 }}, 2002</ref>


It is photoactivated by 732 nm light which allows greater depth of penetration.<ref>http://findarticles.com/p/articles/mi_qa3931/is_200909/ai_n42040200/pg_9/ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009. by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T </ref>
It is photoactivated by 732&nbsp;nm light which allows greater depth of penetration.<ref>http://findarticles.com/p/articles/mi_qa3931/is_200909/ai_n42040200/pg_9/ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009. by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T</ref>


==Clinical trials==
==Clinical trials==
Phase II clinical trials were in progress in 1999.<ref>[http://ir.pharmacyclics.com/releasedetail.cfm?ReleaseID=141812 Antrin® Photoangioplasty Phase II Clinical Trial Patient Treated During Live Case Demonstration at TCT], 1999</ref>
Phase II clinical trials were in progress in 1999.<ref>[http://ir.pharmacyclics.com/releasedetail.cfm?ReleaseID=141812 Antrin Photoangioplasty Phase II Clinical Trial Patient Treated During Live Case Demonstration at TCT] {{Webarchive|url=https://archive.today/20120713142335/http://ir.pharmacyclics.com/releasedetail.cfm?ReleaseID=141812 |date=2012-07-13 }}, 1999</ref>


A phase I trial for [[prostate cancer]] reported in 2009.<ref>{{cite journal | pmid = 18676760 | year = 2008 | last1 = Patel | first1 = H | last2 = Mick | first2 = R | last3 = Finlay | first3 = J | last4 = Zhu | first4 = TC | last5 = Rickter | first5 = E | last6 = Cengel | first6 = KA | last7 = Malkowicz | first7 = SB | last8 = Hahn | first8 = SM | last9 = Busch | first9 = TM | title = Motexafin lutetium-photodynamic therapy of prostate cancer: Short and long term effects on PSA | volume = 14 | issue = 15 | pages = 4869–76 | doi = 10.1158/1078-0432.CCR-08-0317 | pmc = 2680073 | journal = Clinical cancer research : an official journal of the American Association for Cancer Research }}</ref>
A phase I trial for [[prostate cancer]] reported in 2009.<ref>{{cite journal | pmid = 18676760 | year = 2008 | last1 = Patel | first1 = H | last2 = Mick | first2 = R | last3 = Finlay | first3 = J | last4 = Zhu | first4 = TC | last5 = Rickter | first5 = E | last6 = Cengel | first6 = KA | last7 = Malkowicz | first7 = SB | last8 = Hahn | first8 = SM | last9 = Busch | first9 = TM | title = Motexafin lutetium-photodynamic therapy of prostate cancer: Short and long term effects on PSA | volume = 14 | issue = 15 | pages = 4869–76 | doi = 10.1158/1078-0432.CCR-08-0317 | pmc = 2680073 | journal = Clinical Cancer Research }}</ref>


==References==
==References==
{{reflist}}
{{reflist}}


⚫
{{Lutetium compounds}}



[[Category:Tetrapyrroles]]
[[Category:Tetrapyrroles]]
[[Category:Lutetium compounds]]
[[Category:Lutetium complexes]]

⚫
{{Lutetium compounds}}




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