Phorbol 12,13-dibutyrate: Difference between revisions
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{{Chembox |
{{Chembox |
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| ImageFile = Phorbol 12,13-dibutyrate.png |
| ImageFile = Phorbol 12,13-dibutyrate.png |
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| ImageSize = 200px |
| ImageSize = 200px |
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| PIN = (1a''R'',1b''S'',4a''R'',7a''S'',7b''S'',8''R'',9''R'',9a''S'')-4a,7b-Dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9a''H''-cyclopropa[3,4]benzo[1,2-''e'']azulene-9,9a-diyl dibutanoate |
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| IUPACName = |
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| OtherNames = Phorbol dibutyrate; Phorbol 12,13-dibutanoate |
| OtherNames = Phorbol dibutyrate; Phorbol 12,13-dibutanoate |
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|Section1={{Chembox Identifiers |
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| Abbreviations = PDBu |
| Abbreviations = PDBu |
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| CASNo_Ref = {{cascite|correct|??}} |
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| CASNo = 37558-16-0 |
| CASNo = 37558-16-0 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 67MX82CL58 |
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| PubChem = 37783 |
| PubChem = 37783 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 34645 |
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| InChI = 1/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1 |
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| InChIKey = BQJRUJTZSGYBEZ-YVQNUNKEBT |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1 |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = BQJRUJTZSGYBEZ-YVQNUNKESA-N |
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| ChEBI_Ref = {{ebicite|changed|EBI}} |
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| ChEBI = 17598 |
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| KEGG_Ref = {{keggcite|changed|kegg}} |
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| KEGG = C03634}} |
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| Appearance = |
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'''Phorbol 12,13-dibutyrate''' ('''PDBu''') is a [[phorbol ester]] which is one of the constituents of [[croton oil]]. As an activator of [[protein kinase C]], it is a weak tumor promoter compared to [[12-O-Tetradecanoylphorbol-13-acetate|12-''O''- |
'''Phorbol 12,13-dibutyrate''' ('''PDBu''') is a [[phorbol ester]] which is one of the constituents of [[croton oil]]. As an activator of [[protein kinase C]], it is a weak tumor promoter compared to [[12-O-Tetradecanoylphorbol-13-acetate|12-''O''-tetradecanoylphorbol-13-acetate]].<ref>{{cite journal|doi=10.1111/j.1749-6632.1983.tb47836.x|vauthors=Blumberg PM, Delclos KB, Dunn JA, Jaken S, Leach KL, Yeh E | year=1983 | title=Phorbol ester receptors and the in vitro effects of tumor promoters | journal=Annals of the New York Academy of Sciences | volume=407 |issue=1 | pages=303–315|pmid=6309054|bibcode=1983NYASA.407..303B |s2cid=20089027 }}</ref> |
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PDBu is widely used as a chemical reagent because of its [[solubility]] in water and other organic solvents. |
PDBu is widely used as a chemical reagent because of its [[solubility]] in water and other organic solvents. |
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{{reflist}} |
{{reflist}} |
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[[Category: |
[[Category:Butyrate esters]] |
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[[Category:Diterpenes]] |
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[[Category:Alcohols]] |
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[[Category:Ketones]] |
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[[Category:Carcinogens]] |
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[[Category:Cyclopentenes]] |
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[[Category:Phorbol esters]] |