Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Simfibrate: Difference between pages
(Difference between pages)
Content deleted Content added
Saving copy of the {{drugbox}} taken from revid 452131714 of page Simfibrate for the Chem/Drugbox validation project (updated: ''). |
removed Category:Chloroarenes; added Category:4-Chlorophenyl compounds using HotCat |
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{{Short description|Chemical compound}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:Simfibrate|oldid=452131714}} 452131714] of page [[Simfibrate]] with values updated to verified values.}} |
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{{Drugbox |
{{Drugbox |
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| Watchedfields = changed |
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| verifiedrevid = |
| verifiedrevid = 464391792 |
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| IUPAC_name = |
| IUPAC_name = Propane-1,3-diyl bis[2-(4-chlorophenoxy)-2-methylpropanoate] |
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| image = |
| image = Simfibrate.svg |
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<!--Clinical data--> |
<!--Clinical data--> |
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| tradename = |
| tradename = Cholesolvin |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B |
| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
| pregnancy_category = |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- |
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL |
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC |
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
| legal_status = |
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| routes_of_administration = |
| routes_of_administration = |
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<!--Pharmacokinetic data--> |
<!--Pharmacokinetic data--> |
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| bioavailability = |
| bioavailability = |
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| protein_bound = |
| protein_bound = |
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| metabolism = |
| metabolism = |
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| elimination_half-life = |
| elimination_half-life = |
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| excretion = |
| excretion = |
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<!--Identifiers--> |
<!--Identifiers--> |
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| CAS_number = |
| CAS_number = 14929-11-4 |
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| ATC_prefix = C10 |
| ATC_prefix = C10 |
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| ATC_suffix = AB06 |
| ATC_suffix = AB06 |
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| PubChem = 5217 |
| PubChem = 5217 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
| DrugBank = |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 5028 |
| ChemSpiderID = 5028 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=23 | H=26 | Cl=2 | O=6 |
| C=23 | H=26 | Cl=2 | O=6 |
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| molecular_weight = 469.354 g/mol |
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| smiles = Clc2ccc(OC(C(=O)OCCCOC(=O)C(Oc1ccc(Cl)cc1)(C)C)(C)C)cc2 |
| smiles = Clc2ccc(OC(C(=O)OCCCOC(=O)C(Oc1ccc(Cl)cc1)(C)C)(C)C)cc2 |
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| InChI = 1/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3 |
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| InChIKey = JLRNKCZRCMIVKA-UHFFFAOYAQ |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3 |
| StdInChI = 1S/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = JLRNKCZRCMIVKA-UHFFFAOYSA-N |
| StdInChIKey = JLRNKCZRCMIVKA-UHFFFAOYSA-N |
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| synonyms = |
| synonyms = 3-<nowiki>{[</nowiki>2-(4-Chlorophenoxy)-2-methylpropanoyl]oxy}propyl 2-(4-chlorophenoxy)-2-methylpropanoate |
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}} |
}} |
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'''Simfibrate''' ([[Japanese Accepted Name|JAN]]/[[International Nonproprietary Name|INN]]; trade name '''Cholesolvin''') is a [[fibrate]] that has been used for the treatment of [[hyperlipidemia]].<ref>{{Cite journal | doi = 10.22159/ijcpr.2017v9i1.16616 | title = Introduction to Hyperlipidemia and its Treatment: A Review | journal = International Journal of Current Pharmaceutical Research | volume = 9 | pages = 6 | year = 2016 | last1 = Verma | first1 = Niharika | name-list-style = vanc | doi-access = free }}</ref><ref>{{cite journal | vauthors = Olsson AG, Orö L, Rössner S | title = Clinical and metabolic effects of pentaerythritol tetranicotinate in combination with cholesolvin or clofibrate | journal = Atherosclerosis | volume = 19 | issue = 3 | pages = 407–15 | year = 1974 | pmid = 4364073 | doi = 10.1016/S0021-9150(74)80005-5 }}</ref> The substance is a double [[ester]] of [[clofibric acid]] with [[1,3-propanediol]] which is cleaved in the body to one molecule of 1,3-propanediol and two molecules of clofibric acid which is the true [[lipid-lowering agent]]. |
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== References == |
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{{Reflist}} |
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{{Lipid modifying agents}} |
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{{PPAR modulators}} |
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[[Category:4-Chlorophenyl compounds]] |
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[[Category:2-Methyl-2-phenoxypropanoic acid derivatives]] |
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{{cardiovascular-drug-stub}} |
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