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Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers"...

a binding coefficient is a quantity representing the extent to which a chemical compound will bind to a macromolecule. The preferential binding coefficient...

the active site loop. The different conformations ensure that only preferential binding occurs in the active site. In the presence of a slow substrate, Gly794...

In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex. Binding selectivity describes how...

and likely only condense DNA by inducing sharp bending. Besides preferential binding to a specific DNA sequence, IHF also binds to DNA in a non-sequence...

antagonist ligands turn helix 12 away from the LXXLL-binding surface that leads to preferential binding of a longer leucine-rich motif, LXXXIXXX(I/L), present...

blood, about 20% of circulating primaquine is protein-bound, with preferential binding to the acute phase protein orosomucoid. With a half-life on the order...

concomitant with a lowering of the free energy of the transition state. Preferential binding of the transition state is a key feature of enzyme chemistry. The...

proteases preferentially bind the transition state and the overall structure is favored, lowering the activation energy of the reaction. This "preferential binding"...

mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins". Journal of Lipid Research. 41...

structure on small unilamellar vesicles. A preferential binding to small vesicles has been found. The binding of alpha-synuclein to lipid membranes has...

Bogdarina I, Schroeder E, Taylor IA, Kneale GG (August 2000). "Preferential binding of fd gene 5 protein to tetraplex nucleic acid structures". J. Mol...

2006). "Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair". Proceedings...

abundance of acetylated histones in the female's cytoplasm or through preferential binding of the male DNA to acetylated histones. Second, male DNA is systematically...

(i.e. the lone pair closer to the smaller substituent, Rs). This preferential binding in 3 acts to minimize the steric interactions between the ketone...

American young adults (43 with MDD, 47 healthy). Armstrong et al. found preferential binding of IgG from Crohn’s disease patients to F. plautii as compared to...

identification of bindentate binding molecules. Three different sublibraries can be assembled to form a combinatorial triplex library. Preferential binders isolated...

own work. Both DNA microarrays and quantitative PCR exploit the preferential binding or "base pairing" of complementary nucleic acid sequences, and both...

broad specificity for classical and non-classical MHC alleles with preferential binding to b2m-associated complexes. In contrast, the activating receptors...

small molecule Hsp90 inhibitor, PU-H71, has been found to have a preferential binding to Hsp90 when it is in the highly integrated complexed form that...