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{{DEFAULTSORT:Mishra, Anil}}
{{DEFAULTSORT:Mishra, Anil}}
[[Category:Academics]]


[[Category:Indian medical doctors]]
[[Category:Indian medical doctors]]

Revision as of 17:34, 10 April 2024

Anil Mishra is an Indian origin scientist who holds the Edward G. Schlieder Educational Foundation Endowed Chair in the Section of Pulmonary Diseases at Tulane School of Medicine, New Orleans, LA.[1]

Early life & education

Anil Mishra completed his Bachelor of Science at Maharajas College, affiliated with Rajasthan University in Jaipur, India. He pursued further education at Kanpur University, India, where he earned a PhD.[2] His early doctoral research in India was focused on the environmental pollutants' impact on human health, notably following the Bhopal Methyl Isocyanate accident.[3]

Research & career

Throughout his career, Mishra has made significant contributions to the fields of pulmonary diseases and eosinophilic disorders.[4] His research has been pivotal in understanding the health impacts of environmental pollutants and the role of eosinophils in allergic and gastrointestinal diseases.[5][6] Mishra has authored over 120 scholarly articles and book chapters.[7]

Mishra holds a leadership position as a professor of Medicine and directs the Eosinophilic Disorder Centre at Tulane School of Medicine.[8][9]

Awards

Mishra is an elected fellow of the American Academy of Allergy, Asthma & Immunology (FAAAAI) and the American Gastroenterological Association (AGA).[10]

Scientific Achievements

As a Principal investigator of several NIH-funded grants, Dr Mishra laid down the groundwork for the development of an experimental model of eosinophilic esophagitis (EoE) and implicated IL-18 to generate and transform naive IL-5 generated eosinophil into CD274 expressed pathogenic eosinophils. Additionally, his investigations also showed that CD274 expressing pathogenic eosinophils is also the cause of airway hyperactivity in asthma. Recently, he reported that NLRP3-Caspase1-regulated IL- 18 neutralization or respective inhibitors protect allergen induced asthma and EoE and MMP12 antagonists are critical in protecting esophageal and lung fibrosis in disease state.

Notable publications

  • Fundamental Signals that regulate eosinophils.[11]
  • Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.[12]
  • An etiological role for aeroallergens and eosinophils in experimental esophagitis.[13]
  • Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.[14]
  • Pathogenic Mechanisms of pancreatitis.[15]
  • Pathogenic eosinophils subsets[16]
  • IL-18 neutralization therapy for human asthma and eosinophilic esophagitis.[17]

References

  1. ^ "Anil Mishra, PhD | Tulane School of Medicine". medicine.tulane.edu. Retrieved 2024-04-02.
  2. ^ "tulane.edu" (PDF).
  3. ^ Varma, Daya R.; Mulay, Shree (2009-01-01), Gupta, Ramesh C. (ed.), "CHAPTER 21 - Methyl Isocyanate: The Bhopal Gas", Handbook of Toxicology of Chemical Warfare Agents, San Diego: Academic Press, pp. 293–312, doi:10.1016/b978-0-12-374484-5.00021-3, ISBN 978-0-12-374484-5, retrieved 2024-04-02
  4. ^ "Pulmonary Eosinophilic Disorder Center | Tulane School of Medicine". medicine. Tulane.edu. Retrieved 2024-04-02.
  5. ^ Kandikattu, Hemanth Kumar; Upparahalli Venkateshaiah, Sathisha; Mishra, Anil (2019-06-01). "Synergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases". Cytokine & Growth Factor Reviews. 47: 83–98. doi:10.1016/j.cytogfr.2019.05.003. ISSN 1359-6101. PMC 6781864. PMID 31126874.
  6. ^ Kandikattu, Hemanth Kumar; Upparahalli Venkateshaiah, Sathisha; Mishra, Anil (2019-06-01). "Synergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases". Cytokine & Growth Factor Reviews. 47: 83–98. doi:10.1016/j.cytogfr.2019.05.003. ISSN 1359-6101. PMC 6781864. PMID 31126874.
  7. ^ "Index of Sciences Ltd". scholar.google.com. Retrieved 2024-04-02.
  8. ^ Mishra, Anil; Dwivedi, Premendra D.; Verma, Ashish S.; Mishra, Jaya; Sinha, M.; Dutta, K. K.; Ray, P. K. (1991-11-01). "Modulation of microsomal membrane-associated detoxication enzymes activity by methyl isocyanate (MIC) exposure". Bulletin of Environmental Contamination and Toxicology. 47 (5): 675–681. Bibcode:1991BuECT..47..675M. doi:10.1007/BF01701133. ISSN 1432-0800. PMID 1813080.
  9. ^ "usnews.com".
  10. ^ Kandikattu, Hemanth Kumar; Venkateshaiah, Sathisha Upparahalli; Kumar, Sandeep; Mishra, Anil (2020-08-01). "IL-15 immunotherapy is a viable strategy for COVID-19". Cytokine & Growth Factor Reviews. Therapeutic Opportunities in the Management of COVID-19. 54: 24–31. doi:10.1016/j.cytogfr.2020.06.008. ISSN 1359-6101. PMC 7537239. PMID 32536564.
  11. ^ Mishra, A.; Hogan, S. P.; Lee, J. J.; Foster, P. S.; Rothenberg, M. E. (June 1999). "Fundamental signals that regulate eosinophil homing to the gastrointestinal tract". The Journal of Clinical Investigation. 103 (12): 1719–1727. doi:10.1172/JCI6560. ISSN 0021-9738. PMC 408388. PMID 10377178.
  12. ^ Blanchard, Carine; Wang, Ning; Stringer, Keith F.; Mishra, Anil; Fulkerson, Patricia C.; Abonia, J. Pablo; Jameson, Sean C.; Kirby, Cassie; Konikoff, Michael R.; Collins, Margaret H.; Cohen, Mitchell B.; Akers, Rachel; Hogan, Simon P.; Assa’ad, Amal H.; Putnam, Philip E. (2006-02-01). "Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis". The Journal of Clinical Investigation. 116 (2): 536–547. doi:10.1172/JCI26679. ISSN 0021-9738. PMC 1359059. PMID 16453027.
  13. ^ Mishra, A.; Hogan, S. P.; Brandt, E. B.; Rothenberg, M. E. (January 2001). "An etiological role for aeroallergens and eosinophils in experimental esophagitis". The Journal of Clinical Investigation. 107 (1): 83–90. doi:10.1172/JCI10224. ISSN 0021-9738. PMC 198543. PMID 11134183.
  14. ^ Zimmermann, Nives; King, Nina E.; Laporte, Johanne; Yang, Ming; Mishra, Anil; Pope, Sam M.; Muntel, Emily E.; Witte, David P.; Pegg, Anthony A.; Foster, Paul S.; Hamid, Qutayba; Rothenberg, Marc E. (2003-06-15). "Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis". The Journal of Clinical Investigation. 111 (12): 1863–1874. doi:10.1172/JCI17912. ISSN 0021-9738. PMC 161427. PMID 12813022.
  15. ^ Manohar, Murli; Verma, Alok Kumar; Venkateshaiah, Sathisha Upparahalli; Sanders, Nathan L.; Mishra, Anil (2017-02-06). "Pathogenic mechanisms of pancreatitis". World Journal of Gastrointestinal Pharmacology and Therapeutics. 8 (1): 10–25. doi:10.4292/wjgpt.v8.i1.10. ISSN 2150-5349. PMC 5292603. PMID 28217371.
  16. ^ Venkateshaiah, S.U.; Mishra, A.; Manohar, M.; Verma, A.K.; Rajavelu, P.; Niranjan, R.; Wild, L.G.; Parada, N.A.; Blecker, U.; Lasky, J.A.; Mishra, A. (2018). "A critical role for IL-18 in transformation and maturation of naive eosinophils to pathogenic eosinophils". Journal of Allergy and Clinical Immunology. 142 (1): 301–305. doi:10.1016/j.jaci.2018.02.011. PMC 6035772.
  17. ^ Yadavalli, Chandra Sekhar; Upparahalli Venkateshaiah, Sathisha; Kumar, Sandeep; Kandikattu, Hemanth Kumar; Oruganti, Lokanatha; Kathera, Chandra Sekhar; Mishra, Anil (2023-07-31). "Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis". Communications Biology. 6 (1): 763. doi:10.1038/s42003-023-05130-4. ISSN 2399-3642. PMC 10390481. PMID 37524769.

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