Laurence H. Kedes

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Laurence H. Kedes
Kedes in 2014
Born
Laurence H. Kedes

July 19, 1937 (1937-07-19)
Hartford, Connecticut, U.S.
DiedJanuary 6, 2021(2021-01-06) (aged 83)
Alma materWesleyan University
Stanford University (BS, 1961; MD, 1962)
SpouseShirley (née Beck) Kedes
Children3
Awards
Scientific career
FieldsMolecular Biology
Genetics
Genomics
Institutions

Laurence (Larry) H. Kedes (born July 19, 1937, died January 6, 2021[1]) was an American scientist in the fields of gene expression, genomics, and cellular differentiation. His first faculty position was at Stanford University (1970-1989) where he rose to full professor in the Department of Medicine and focused on basic molecular biology and gene expression. In 1988, the University of Southern California (USC) recruited Kedes to spearhead a campus-wide initiative to strengthen their molecular biology and genetics research programs. At USC, Kedes conceived and developed the Institute of Genetic Medicine,[2] becoming its founding director (1989-2008) as well as the William Keck Professor (1988-2009) and Chair (1988-2002) of the Department of Biochemistry and Molecular Biology.[3]

Education

Kedes attended Weaver High School,[4] in Hartford, Connecticut and then earned his BS in Biology from Stanford University in 1961 after completing 3 years (1957-1959) of undergraduate studies at Wesleyan University (Connecticut), which later recognized him as a Distinguished Alumnus, awarding him an honorary bachelor's of arts degree (2009).[5] Kedes earned his medical degree from Stanford University Medical School (1958-1962) and then completed his internship and junior year of residency in internal medicine at the University of Pittsburgh (1962-1964), followed by two years of research at the Laboratory of Biochemistry and Biology Branch,[6] within the National Cancer Institute (1964-1966). Following a senior residency year at the Brigham and Women's Hospital, Kedes joined the laboratory of Paul R. Gross at the Massachusetts Institute of Technology, completing his postdoctoral research fellowship.[7][8] Supported by a Leukemia Society award, he then worked for one year (1969-1970) in Europe, most notably with embryologist, Alberto Monroy, and molecular biologist Max Birnstiel.[9]

Career

Kedes was recruited to Stanford University (1970-1989), where he rose to the rank of full professor and became that institution's first investigator supported by the Howard Hughes Medical Institute (1974-1982).[10] While at Stanford, he was a founder of IntelliGenetics (later IntelliCorp) (1980-1987), the first company focused on designing and applying computer programs, expert systems, and artificial intelligence to the analysis of DNA sequences. There, Kedes held the positions of Senior Scientist and Chairman. In 1989, Kedes moved to USC where he conceptualized, obtained extramural funding for, and oversaw the design and building of the Institute of Genetic Medicine.[2] The institute followed a collaboratory model and Kedes recruited 20 faculty to the IGM during his tenure as its founding director. He also served as Scientific Director and Co-Chair of the Scientific Advisory Board for the Archon X PRIZE in Genomics (2005-2013) and was the Weston Visiting Professor at the Weitzmann Institute (2009),[11] Following his retirement from USC, Kedes served as Interim Director of Medical Genetics at Cedars Sinai Medical Center (2012-2014). Kedes authored over 220 papers, reviews, and book chapters. His published work has over 23,000 citations with two papers receiving over 1000 citations each and over 45 receiving over 100 citations each, as of 2016.[12]

Awards and honors

Research and scientific contributions

Kedes was an internationally recognized expert in the field of skeletal muscle and cardiac muscle molecular genetics with scientific contributions to molecular biology and gene expression that spanned over four decades. Among his scientific achievements was the first isolation of a protein-coding gene from an animal cell,[15][16] and he was the first to determine the DNA sequence of a protein coding animal gene.[17] His initial research focused on understanding the chromosomal arrangement, sequences, and regulation of the multi-gene family encoding histone proteins, which later proved to play a central role in controlling overall gene expression, including the formation of eu- and heterochromatin (see histone code). The second phase of his research delved into the study of the regulation of actin genes, another multi-gene family. During this period, Kedes recognized evolutionarily conserved elements within non-coding regions of the 3' ends of mRNAs,[18][19] and predicted that these regions were likely targets of post-transcriptional regulation, which later proved to be correct (see, for example, MicroRNA, AU-rich element, Three prime untranslated region). In the third phase of his research, Kedes turned his attention to muscle gene expression and myocyte differentiation and transdifferentiation, including early forays into cardiac gene therapy.[20] He was also a developer of the first federally funded digital web-based database for storing and analyzing DNA sequences,[21][22] laying the foundation, along with the Los Alamos National Laboratory, for the development of subsequent NIH databases, including GenBank at the NCBI. Seeing the need to develop sophisticated expert systems to analyze increasingly complex sets of DNA databases, Kedes initiated collaborations with fellow Stanford University molecular biologist Douglas Brutlag and computer scientists Peter Friedland and Edward Feigenbaum and sought and obtained federal funding to establish a pre-internet era resource to share openly both the DNA sequence data and the mainframe computer aided analysis software in a program that they named Bionet.[23] These four faculty, together, formed Intelligenetics,[24] which was the first entity that managed Bionet.

Personal life

The son of Rosalyn and Samuel Kedes, Larry Kedes was born in Hartford, Connecticut. He married Shirley Beck in 1958. They had three children, Dean Kedes (born 1960), Maureen Kedes (born 1962), and Todd Kedes (born 1966).[1] He had a younger sister, Judith Kedes (1941 – 2016).

References

  1. ^ a b "In memoriam: Laurence H. Kedes, MD". Keck School of Medicine of USC. January 19, 2021.
  2. ^ a b "History | Institute for Genetic Medicine (IGM)". Keck.usc.edu. 2014-06-20. Retrieved 2016-11-23.
  3. ^ [1]
  4. ^ "Hartford Budget Woes Won't Halt Weaver High School Renovation - Courant Community". Courant.com. 2016-03-31. Retrieved 2016-11-23.
  5. ^ "r. David J. Sencer '46 and Dr. Laurence H. Kedes '59 each received an honorary Bachelor of Arts degree. | News @ Wesleyan". Newsletter.blogs.wesleyan.edu. 2009-05-24. Retrieved 2016-11-23.
  6. ^ [2]
  7. ^ Kedes, LH; Gross, PR (2016-11-15). "Identification in cleaving embryos of three RNA species serving as templates for the synthesis of nuclear proteins". Nature. 223 (5213): 1335–9. doi:10.1038/2231335a0. PMID 5809508.
  8. ^ Kedes, LH; Gross, PR (2016-11-15). "Synthesis and function of messenger RNA during early embryonic development". J Mol Biol. 42 (3): 559–75. doi:10.1016/0022-2836(69)90243-5. PMID 4979625.
  9. ^ Kedes, LH; Birnstiel, ML (2016-11-15). "Reiteration and clustering of DNA sequences complementary to histone messenger RNA". Nat New Biol. 230 (14): 165–9. doi:10.1038/newbio230165a0. PMID 5279989.
  10. ^ "Alumni | Howard Hughes Medical Institute". HHMI.org. Retrieved 2016-11-23.
  11. ^ "Visiting Professors Program | Academic Affairs Office". Weizmann.ac.il. Retrieved 2016-11-23.
  12. ^ "Larry Kedes - Google Scholar Citations". Scholar.google.com. Retrieved 2016-11-23.
  13. ^ [3] [dead link]
  14. ^ "Scientific Advisory Board | Archon Genomics XPRIZE". Genomics.xprize.org. Retrieved 2016-11-23.
  15. ^ Kedes, Laurence H.; Chang, Annie C. Y.; Houseman, David; Cohen, Stanley N. (1975-06-12). "Isolation of histone genes from unfractionated sea urchin DNA by subculture cloning in E. coli". Nature. 255 (5509): 533–538. doi:10.1038/255533a0. Retrieved 2016-11-23.
  16. ^ "Review : Offerings from an Urchin" (PDF). Ase.tufts/edu. Retrieved 2016-11-23.
  17. ^ Grunstein, M; Levy, S; Schedl, P; Kedes, L (2016-11-15). "Messenger RNAs for individual histone proteins: fingerprint analysis and in vitro translation". Cold Spring Harb Symp Quant Biol. 38: 717–24. doi:10.1101/SQB.1974.038.01.077. PMID 4524784.
  18. ^ Gunning, P; Mohun, T; Ng, SY; Ponte, P; Kedes, L (2016-11-15). "Evolution of the human sarcomeric-actin genes: evidence for units of selection within the 3' untranslated regions of the mRNAs". J Mol Evol. 20 (3–4): 202–14. doi:10.1007/bf02104727. PMID 6439877.
  19. ^ Ponte, P; Gunning, P; Blau, H; Kedes, L (2016-11-15). "Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated ..." Mol. Cell. Biol. 3 (10): 1783–91. doi:10.1128/MCB.3.10.1783. PMC 370040. PMID 6646124.
  20. ^ Müller-Ehmsen, J; Whittaker, P; Kloner, RA; et al. (2016-11-15). "Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium". J. Mol. Cell. Cardiol. 34 (2): 107–16. doi:10.1006/jmcc.2001.1491. PMID 11851351.
  21. ^ Smith, DH; Brutlag, D; Friedland, P; Kedes, LH (2016-11-15). "BIONET: national computer resource for molecular biology". Nucleic Acids Res. 14: 17–20. doi:10.1093/nar/14.1.17. PMC 339350. PMID 3945548.
  22. ^ "Letter from Stanford University Medical Center" (PDF). Profiles.nlm.nih.gov. 1980-08-29. Retrieved 2016-11-23.
  23. ^ "BIONET"11: national computer resource for molecular biology" (PDF). Nar.oxfordjournals.org. Retrieved 2016-11-23.[dead link]
  24. ^ "History of IntelliCorp, Inc. – FundingUniverse". Fundinguniverse.com. Retrieved 2016-11-23.
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