Philanthotoxin

delta-Philathotoxin
Names
	IUPAC name N-[(2S)-1-[4-[3-(3-Aminopropylamino)propylamino]butylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide
Identifiers
CAS Number	77108-00-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1160514 ;
PubChem CID	115201;
CompTox Dashboard (EPA)	DTXSID80896963 ;
	SMILES CCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NCCCCNCCCNCCCN;
Properties
Chemical formula	C23H41N5O3
Molar mass	435.603 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Philanthotoxins are components of the venom of Egyptian solitary wasp Philanthus triangulum F and four toxins are distinguished (alpha, beta, gamma, delta) among which delta-philanthotoxin (dPTX) is most effective to block glutamate receptors^[1] and especially those quisqualate-sensitive, that is AMPA receptor^[2]. It has later been shown that dPTX targets calcium permeable AMPA receptor and kainate receptor but not NMDA receptor.^[3]

References

^ Piek T (1982) Comp Biochem Physiol C 72:311-315
^ Clark RB, Donaldson PL, Gration KAF, Lambert JJ, Piek T, Ramsey RL, Spanjer, Usheerwood PNR (1982) Brain Research 241:105-114
^ Jones MJ, Anis NA, Lodge D (1990) Br J Pharmacol 101(4):968-970

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[1] Piek T (1982) Comp Biochem Physiol C 72:311-315

[2] Clark RB, Donaldson PL, Gration KAF, Lambert JJ, Piek T, Ramsey RL, Spanjer, Usheerwood PNR (1982) Brain Research 241:105-114

[3] Jones MJ, Anis NA, Lodge D (1990) Br J Pharmacol 101(4):968-970

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