Quinpirole: Difference between revisions

Browse history interactively
Page 1
Page 2
← Previous edit
Content deleted Content added
VisualWikitext
No edit summary
Citation bot (talk | contribs)
Bots
4,923,194 edits
Add: s2cid, doi, authors 1-1. Removed parameters. Some additions/deletions were parameter name changes. | Use this bot. Report bugs. | Suggested by Abductive | Category:Psychoactive drug stubs | #UCB_Category 72/182
 
(43 intermediate revisions by 28 users not shown)
Line 1: Line 1:
{{chembox
{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 396961061
| ImageFile = Quinpirole.png
| ImageFile = Quinpirole.png
| ImageSize =
| ImageSize =
| IUPACName = (4a''R'',8a''R'')-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1''H''-pyrazolo[3,4-''g'']quinoline
| PIN = (4a''R'',8a''R'')-5-Propyl-4,4a,5,6,7,8,8a,9-octahydro-1''H''-pyrazolo[3,4-''g'']quinoline
| OtherNames =
| OtherNames =
| Section1 = {{Chembox Identifiers
| Section1 = {{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 80373-22-4
| CASNo = 80373-22-4
| PubChem = 54562
| PubChem = 54562
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 75401
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 240773
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = 20OP60125T

| IUPHAR_ligand = 2
| IUPHAR_ligand = 2
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| SMILES = }}
| ChemSpiderID = 49279
| SMILES = CCCN1CCC[C@H]2[C@H]1CC3=C(C2)NN=C3
| InChI = 1/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
| InChIKey = FTSUPYGMFAPCFZ-ZWNOBZJWBQ
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = FTSUPYGMFAPCFZ-ZWNOBZJWSA-N
| RTECS =
| MeSHName = D019257}}
| Section2 = {{Chembox Properties
| Section2 = {{Chembox Properties
| Formula =
| Formula =
Line 21: Line 42:
| MainHazards =
| MainHazards =
| FlashPt =
| FlashPt =
| Autoignition = }}
| AutoignitionPt = }}
}}
}}


'''Quinpirole''' is a [[psychoactive drug]] and [[research chemical]] which acts as a [[functional selectivity|selective]] [[D2 receptor|D<sub>2</sub>]] and [[D3 receptor|D<sub>3</sub>]] [[receptor (biochemistry)|receptor]] [[agonist]]. It is used in [[scientific research]].<ref name="pmid2566488">{{cite journal |author=Eilam D, Szechtman H |title=Biphasic effect of D-2 agonist quinpirole on locomotion and movements |journal=European Journal of Pharmacology |volume=161 |issue=2-3 |pages=151–7 |year=1989 |month=February |pmid=2566488 |doi= |url=}}</ref><ref name="pmid10544391">{{cite journal |author=Navarro JF, Maldonado E |title=Behavioral profile of quinpirole in agonistic encounters between male mice |journal=Methods and Findings in Experimental and Clinical Pharmacology |volume=21 |issue=7 |pages=477–80 |year=1999 |month=September |pmid=10544391 |doi= |url=}}</ref><ref name="pmid15138441">{{cite journal |author=Culm KE, Lugo-Escobar N, Hope BT, Hammer RP |title=Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats |journal=Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology |volume=29 |issue=10 |pages=1823–30 |year=2004 |month=October |pmid=15138441 |doi=10.1038/sj.npp.1300483 |url=}}</ref> It has been shown to increase locomotion and sniffing behavior in mice who have been treated with this.
'''Quinpirole''' is a [[psychoactive drug]] and [[research chemical]] which acts as a [[functional selectivity|selective]] [[D2 receptor|D<sub>2</sub>]] and [[D3 receptor|D<sub>3</sub>]] [[receptor (biochemistry)|receptor]] [[agonist]]. It is used in [[scientific research]].<ref name="pmid2566488">{{cite journal |vauthors=Eilam D, Szechtman H |title=Biphasic effect of D-2 agonist quinpirole on locomotion and movements |journal=European Journal of Pharmacology |volume=161 |issue=2–3 |pages=151–7 |date=February 1989 |pmid=2566488 |doi= 10.1016/0014-2999(89)90837-6}}</ref><ref name="pmid10544391">{{cite journal |vauthors=Navarro JF, Maldonado E |title=Behavioral profile of quinpirole in agonistic encounters between male mice |journal=Methods and Findings in Experimental and Clinical Pharmacology |volume=21 |issue=7 |pages=477–80 |date=September 1999 |doi=10.1358/mf.1999.21.7.550110 |pmid=10544391 |s2cid=25978291 }}</ref><ref name="pmid15138441">{{cite journal |vauthors=Culm KE, Lugo-Escobar N, Hope BT, Hammer RP |title=Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats |journal=Neuropsychopharmacology |volume=29 |issue=10 |pages=1823–30 |date=October 2004 |pmid=15138441 |doi=10.1038/sj.npp.1300483 |doi-access=free }}</ref> Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. At least one study has found that quinpirole induces compulsive behavior symptomatic of [[obsessive compulsive disorder]] in rats.<ref>{{cite journal|doi=10.1037/0735-7044.112.6.1475|title=Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)|year=1998|last1=Szechtman|first1=Henry|last2=Sulis|first2=William|last3=Eilam|first3=David|journal=Behavioral Neuroscience|volume=112|issue=6|pages=1475–85|pmid=9926830|hdl=11375/26795|hdl-access=free}}</ref> Another study in rats show that quinpirole produces significant [[Tetrahydrocannabinol|THC]]-like effects when metabolic degradation of [[anandamide]] is inhibited, supporting the hypothesis that these effects of quinpirole are mediated by [[Cannabinoid receptor|cannabinoid]] [[Cannabinoid receptor type 1|CB<sub>1</sub> receptors]].<ref>{{Cite journal|last1=Solinas|first1=Marcello|last2=Tanda|first2=Gianluigi|last3=Wertheim|first3=Carrie E.|last4=Goldberg|first4=Steven R.|date=2016-10-08|title=Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide|pmc=2834964|journal=Psychopharmacology|volume=209|issue=2|pages=191–202|doi=10.1007/s00213-010-1789-8|issn=0033-3158|pmid=20179908}}</ref> Quinpirole may also reduce relapse in adolescent rat models of cocaine addiction.<ref>{{Cite journal|last1=Zbukvic|first1=Isabel C.|last2=Ganella|first2=Despina E.|last3=Perry|first3=Christina J.|last4=Madsen|first4=Heather B.|last5=Bye|first5=Christopher R.|last6=Lawrence|first6=Andrew J.|last7=Kim|first7=Jee Hyun|date=2016-06-01|title=Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats|journal=Cerebral Cortex|language=en|volume=26|issue=6|pages=2895–2904|doi=10.1093/cercor/bhw051|pmid=26946126|issn=1047-3211|pmc=4869820}}</ref>


Experiments in flies found quinpirole may have [[neuroprotective]] effects against [[Parkinson's disease]]-like pathology.<ref name="pmid23452092">{{cite journal | vauthors = Wiemerslage L, Schultz BJ, Ganguly A, Lee D | title = Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture. | journal = J Neurochem | volume = 126 | issue = 4 | pages = 529–40 | year = 2013 | pmid = 23452092 | doi = 10.1111/jnc.12228 | pmc=3737274}}</ref> Moreover, in primary neuronal cultures it also reduces the rate of firing in dopaminergic neurons.<ref name="pmid23452092" />
⚫
{{pharmacology-stub}}


==See also==
==See also==
Line 33: Line 54:
== References ==
== References ==
{{Reflist}}
{{Reflist}}




{{Dopaminergics}}
{{Dopaminergics}}


[[Category:Pyrazoloquinolines]]
[[Category:Pyrazoloquinolines]]
[[Category:Dopamine agonists]]


⚫
{{psychoactive-stub}}
Retrieved from "https://en.wikipedia.org/wiki/Special:ComparePages"