Carboxyamidotriazole: Difference between revisions
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Updating {{chembox}} (no changed fields - added verified revid - updated 'UNII_Ref', 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation ( |
Michael7604 (talk | contribs) recategorized from Chlorobenzenes to Chlorobenzene derivatives |
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|IUPACName= |
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| PIN = 5-Amino-1-{[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl}-1''H''-1,2,3-triazole-4-carboxamide |
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|Section1={{Chembox Identifiers |
|Section1={{Chembox Identifiers |
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| CASNo_Ref = {{cascite|correct|??}} |
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| CASNo= 99519-84-3 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 6ST3ZF52WB |
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| EINECS = 804-580-3 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 97232 |
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| InChI = 1/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27) |
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| InChIKey = WNRZHQBJSXRYJK-UHFFFAOYAY |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C17H12Cl3N5O2/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25/h1-6H,7,21H2,(H2,22,27) |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = WNRZHQBJSXRYJK-UHFFFAOYSA-N |
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|Section2={{Chembox Properties |
|Section2={{Chembox Properties |
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| Formula=C<sub>17</sub>H<sub>12</sub>Cl<sub>3</sub>N<sub>5</sub>O<sub>2</sub> |
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| MolarMass=424.66848 |
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|Section3={{Chembox Hazards |
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'''Carboxyamidotriazole''' is a [[calcium channel blocker]] that blocks voltage-gated and ligand-gated [[calcium channel]]s and has been investigated as an anti-cancer drug ''[[in vitro]]''.<ref>{{cite journal|pmid=9816048|year=1995|last1=Figg|first1=W. D.|last2=Cole|first2=K. A.|last3=Reed|first3=E.|last4=Steinberg|first4=S. M.|last5=Piscitelli|first5=S. C.|last6=Davis|first6=P. A.|last7=Soltis|first7=M. J.|last8=Jacob|first8=J.|last9=Boudoulas|first9=S.|last10=Goldspiel|first10=B.|title=Pharmacokinetics of orally administered carboxyamido-triazole, an inhibitor of calcium-mediated signal transduction|journal=Clinical Cancer Research |volume=1|issue=8|pages=797–803}}</ref><ref>{{cite journal|pmid=30338034|pmc=6188062|year=2018|last1=Bonnefond|first1=M. L.|last2=Florent|first2=R.|last3=Lenoir|first3=S.|last4=Lambert|first4=B.|last5=Abeilard|first5=E.|last6=Giffard|first6=F.|last7=Louis|first7=M. H.|last8=Elie|first8=N.|last9=Briand|first9=M.|last10=Vivien|first10=D.|last11=Poulain|first11=L.|last12=Gauduchon|first12=P.|last13=n'Diaye|first13=M.|title=Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-BCLX<sub>L</sub> strategies through MCL-1 down-regulation|journal=Oncotarget|volume=9|issue=74|pages=33896–33911|doi=10.18632/oncotarget.26084}}</ref> |
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'''Carboxyamidotriazole''' is a [[calcium channel blocker]]. |
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==References== |
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{{reflist}} |
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{{Calcium channel blockers}} |
{{Calcium channel blockers}} |
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[[Category:Calcium channel blockers]] |
[[Category:Calcium channel blockers]] |
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[[Category: |
[[Category:Chlorobenzene derivatives]] |
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[[Category: |
[[Category:Aromatic ketones]] |
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[[Category:Triazoles]] |
[[Category:Triazoles]] |
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[[Category: |
[[Category:Carboxamides]] |
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{{antineoplastic-drug-stub}} |