Propacetamol: Difference between revisions
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Updating {{drugbox}} (changes to verified fields - updated 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation (report [[Wikipedia talk:Wi |
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{{Short description|Chemical compound}} |
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{{drugbox |
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{{Drugbox |
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| image = Propacetamol-2d-skeletal.png |
| image = Propacetamol-2d-skeletal.png |
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<!--Clinical data--> |
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| tradename = |
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| Drugs.com = {{drugs.com|international|propacetamol}} |
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⚫ | | routes_of_administration = [[intravenous|IV]]<ref name="pmid1633071" /><ref name="pmid15367329">{{ cite journal |vauthors=Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P | title = Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial <nowiki>[ISRCTN71723173]</nowiki> | journal = BMC Anesthesiology | year = 2004 | volume = 4 | issue = 1 | pages = 6 | pmc = 520811 | pmid = 15367329 | doi = 10.1186/1471-2253-4-6 | doi-access = free }}</ref> |
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<!--Pharmacokinetic data--> |
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⚫ | | elimination_half-life = 2.4 hours <ref name="pmid1633071">{{ cite journal |vauthors=Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A | title = Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol | journal = British Journal of Clinical Pharmacology | year = 1992 | volume = 34 | issue = 1 | pages = 79–81 | pmc = 1381380 | pmid = 1633071 | doi=10.1111/j.1365-2125.1992.tb04112.x}}</ref> |
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<!--Identifiers--> |
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| CAS_number = 66532-85-2 |
| CAS_number = 66532-85-2 |
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| ATC_prefix = N02 |
| ATC_prefix = N02 |
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| ATC_suffix = BE05 |
| ATC_suffix = BE05 |
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| PubChem = 68865 |
| PubChem = 68865 |
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| molecular_weight = 264.3202 g/mol |
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| ChemSpiderID = 62097 |
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<!--Chemical data--> |
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⚫ | | elimination_half-life = 2.4 hours <ref name="pmid1633071">{{cite journal | |
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| smiles = CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C |
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| pregnancy_category = |
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| StdInChI = 1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17) |
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⚫ | | routes_of_administration = [[intravenous|IV]]<ref name="pmid1633071" |
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| StdInChIKey = QTGAJCQTLIRCFL-UHFFFAOYSA-N |
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'''Propacetamol''' is a [[prodrug]] form of [[paracetamol]] which is formed from esterification of paracetamol, and the carboxylic acid |
'''Propacetamol''' is a [[prodrug]] form of [[paracetamol]] which is formed from [[esterification]] of paracetamol, and the [[carboxylic acid]] diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by [[Intravenous therapy|I.V.]]<ref name="pmid15367329"/> It is given if the patient is unable to take oral or rectally delivered paracetamol and [[nonsteroidal anti-inflammatory drug]]s (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally.<ref name="pmid15790675">{{ cite journal |vauthors=Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA | title = Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery | journal = British Journal of Anaesthesiology | year = 2005 | volume = 94 | issue = 5 | pages = 642–648 | doi = 10.1093/bja/aei109 | pmid = 15790675 | doi-access = free }}</ref> |
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2 grams of propacetamol are equivalent to 1g of paracetamol.<ref name="pmid14756388">{{ cite journal |vauthors=Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A | title = Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects | journal = International Journal of Clinical Pharmacology and Therapeutics | year = 2004 | volume = 42 | issue = 1 | pages = 50–57 | pmid = 14756388 | doi = 10.5414/cpp42050}}</ref> |
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== See also == |
== See also == |
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* [[ |
* [[Phenacetin]] |
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== References == |
== References == |
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{{ |
{{reflist}} |
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{{Analgesics}} |
{{Analgesics}} |
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{{Prostanoidergics}} |
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{{Cannabinoids}} |
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[[Category:Acetanilides]] |
[[Category:Acetanilides]] |
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[[Category:Phenol ethers]] |
[[Category:Phenol ethers]] |
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[[Category:Carboxylate esters]] |
[[Category:Carboxylate esters]] |
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[[Category: |
[[Category:Diethylamino compounds]] |
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{{nervous-system-drug-stub}} |
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{{analgesic-stub}} |
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[[de:Propacetamol]] |