Dimethylglycine: Difference between revisions

| verifiedrevid = 443691631

| Name = ''N'',''N''-Dimethylglycine

| ImageSize =

| ImageFile1=Dimethylglycine 3D.png

| OtherNames = 2-(dimethylamino)acetic acid

| Section1 = {{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| KEGG_Ref = {{keggcite|correct|kegg}}

| InChI = 1/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)

| InChIKey = FFDGPVCHZBVARC-UHFFFAOYAX

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| CASNo = 1118-68-9

| CASNo_Ref = {{cascite|correct|CAS}}

| EC-number = 214-267-8

| PubChem = 673

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank = DB02083

| ChEBI_Ref = {{ebicite|correct|EBI}}

| ChEBI = 58251

| SMILES = O=C(O)CN(C)C

| MeSHName = Dimethylglycine

}}

| Section2 = {{Chembox Properties

| Formula = C₄H₉NO₂

| MolarMass = 103.12 g/mol

| Appearance =

| Density =

| MeltingPt =

| BoilingPt =

| Solubility =

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| Section7= {{Chembox Hazards

| EUIndex =

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| Autoignition =

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'''Dimethylglycine''' ('''DMG''') is a derivative of the [[amino acid]] [[glycine]] with the structural formula (CH₃)₂NCH₂COOH. It can be found in beans and liver. It can be formed from [[trimethylglycine]] upon the loss of one of its [[methyl group]]s. It is also a byproduct of the metabolism of [[choline]].

When DMG was first discovered, it was referred to as vitamin B₁₆, but, unlike true [[B vitamin]]s, deficiency of DMG in the diet does not lead to any ill-effects meaning it does not meet the definition of a [[vitamin]]. In legal terms, it has been deemed a food product and, as such, is available without a practitioner or prescription.

== Uses ==

Dimethylglycine has been suggested for use as an [[Performance-enhancing drugs|athletic performance enhancer]], [[immunostimulant]], and a treatment for [[autism]], [[epilepsy]], or [[mitochondrial disease]].<ref>{{cite web |title=Dimethylglycine |url=http://www.mskcc.org/mskcc/html/69204.cfm |publisher=[[Memorial Sloan–Kettering Cancer Center]] |date=December 8, 2009 |work=About Herbs, Botanicals & Other Products}}</ref><ref name="Chinnery2006">{{cite journal |author=Chinnery P, Majamaa K, Turnbull D, Thorburn D |title=Treatment for mitochondrial disorders |journal=[[Cochrane Database of Systematic Reviews (Online)]] |volume= |issue=1 |pages=CD004426 |year=2006 |pmid=16437486 |doi=10.1002/14651858.CD004426.pub2 |url=}}</ref> Published studies on the subject have shown little to no difference between DMG treatment and [[placebo]].<ref>{{cite journal |author=Bolman WM, Richmond JA |title=A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder |journal=Journal of Autism and Developmental Disorders |volume=29 |issue=3 |pages=191–4 |year=1999 |month=June |pmid=10425581}}</ref><ref>{{cite journal |author=Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M |title=Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder |journal=Journal of Child Neurology |volume=16 |issue=3 |pages=169–73 |year=2001 |month=March |pmid=11305684 |url=http://jcn.sagepub.com/cgi/pmidlookup?view=long&pmid=11305684}}</ref>

== References ==

{{Reflist}}

{{Neurotransmitters}}

{{Glycinergics}}

[[Category:Amino acids]]

[[Category:Dietary supplements]]

[[fr:Diméthylglycine]]

{{biochem-stub}}