Romifidine: Difference between revisions

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{{Short description|Chemical compound}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
| Verifiedfields = changed
| verifiedrevid = 416492895
| verifiedrevid = 448113917
| IUPAC_name = N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
| IUPAC_name = ''N''-(2-bromo-6-fluorophenyl)-4,5-dihydro-1''H''-imidazol-2-amine
| image = Romifidine.png
| image = Romifidine.svg


<!--Clinical data-->
<!--Clinical data-->
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = Veterinary Use
| legal_status = Veterinary use only
| routes_of_administration = IV
| routes_of_administration = IV


Line 23: Line 24:
| metabolism =
| metabolism =
| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =


<!--Identifiers-->
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 65896-16-4
| CAS_number = 65896-16-4
| ATCvet = yes
| ATCvet = yes
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| DrugBank =
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 876351L05K
| UNII = 876351L05K
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 64975


<!--Chemical data-->
<!--Chemical data-->
| C=9 | H=9 | Br=1 | F=1 | N=3
| C=9 | H=9 | Br=1 | F=1 | N=3
| molecular_weight = 258.09
| smiles = C1CN=C(N1)NC2=C(C=CC=C2Br)F
| smiles = C1CN=C(N1)NC2=C(C=CC=C2Br)F
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C9H9BrFN3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = KDPNLRQZHDJRFU-UHFFFAOYSA-N
}}
}}


'''Romifidine''' is a [[medication|drug]] that is used in [[veterinary medicine]] as a sedative mainly in large animals such as horses,<ref>Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses. ''American Journal of Veterinary Research''. 2005 Nov;66(11):1992-8. PMID 16334961</ref> although it may be used in a wide variety of species.<ref>De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. ''Journal of Veterinary Medicine A. Physiology, Pathology, Clinical Medicine''. 2007 Feb;54(1):48-50. PMID 17359455</ref><ref>Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. ''Veterinary Record''. 2008 Jan 19;162(3):82-7. PMID 18204032</ref> It is not used in humans, but is closely related in structure to the commonly used drug [[clonidine]].
'''Romifidine''' is a [[medication|drug]] that is used in [[veterinary medicine]] as a sedative mainly in large animals such as horses,<ref>{{cite journal | vauthors = Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U | title = Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses | journal = American Journal of Veterinary Research | volume = 66 | issue = 11 | pages = 1992–8 | date = November 2005 | pmid = 16334961 | doi = 10.2460/ajvr.2005.66.1992 | doi-access = free }}</ref> although it may be used in a wide variety of species.<ref>{{cite journal | vauthors = De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI | title = Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine | journal = Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine | volume = 54 | issue = 1 | pages = 48–50 | date = February 2007 | pmid = 17359455 | doi = 10.1111/j.1439-0442.2007.00910.x | doi-access = free }}</ref><ref>{{cite journal | vauthors = Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A | title = Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats | journal = The Veterinary Record | volume = 162 | issue = 3 | pages = 82–7 | date = January 2008 | pmid = 18204032 | doi = 10.1136/vr.162.3.82 | s2cid = 41300654 }}</ref> It is not used in humans, but is closely related in structure to the commonly used drug [[clonidine]].


Romifidine acts as an [[agonist]] at the α<sub>2</sub> [[adrenergic receptor]] subtype. Side effects can include [[bradycardia]] and [[respiratory depression]]. It is often used alongside other sedative or analgesic drugs such as [[ketamine]] or [[butorphanol]].<ref>Corletto F, Raisis AA, Brearley JC. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. ''Veterinary Anaesthesia and Analgesia''. 2005 Jan;32(1):16-22. PMID 15663735</ref><ref>Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. ''Canadian Journal of Veterinary Research''. 2004 Oct;68(4):274-82. PMID 15581222</ref> [[Yohimbine]] can be used as an [[antidote]] to rapidly reverse the effects.
Romifidine acts as an [[agonist]] at the α<sub>2</sub> [[adrenergic receptor]] subtype. Side effects can include [[bradycardia]] and [[respiratory depression]]. It is often used alongside other sedative or analgesic drugs such as [[ketamine]] or [[butorphanol]].<ref>{{cite journal | vauthors = Corletto F, Raisis AA, Brearley JC | title = Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies | journal = Veterinary Anaesthesia and Analgesia | volume = 32 | issue = 1 | pages = 16–22 | date = January 2005 | pmid = 15663735 | doi = 10.1111/j.1467-2995.2004.00184.x }}</ref><ref>{{cite journal | vauthors = Kerr CL, McDonell WN, Young SS | title = Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse | journal = Canadian Journal of Veterinary Research | volume = 68 | issue = 4 | pages = 274–82 | date = October 2004 | pmid = 15581222 | pmc = 1111358 }}</ref> [[Yohimbine]] can be used as an [[antidote]] to rapidly reverse the effects.


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== References ==

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==References==
{{reflist|2}}
{{reflist|2}}



⚫
{{Adrenergic agonists}}
{{Hypnotics and sedatives}}
{{Hypnotics and sedatives}}
⚫
{{Adrenergic receptor modulators}}


[[Category:Analgesics]]
[[Category:Analgesics]]
[[Category:Anesthetics]]
[[Category:Alpha-2 adrenergic receptor agonists]]
[[Category:Alpha-adrenergic agonists]]
[[Category:Organobromides]]
[[Category:Organobromides]]
[[Category:Organofluorides]]
[[Category:Fluoroarenes]]
[[Category:Anilines]]
[[Category:Anilines]]
[[Category:Sedatives]]
[[Category:Imidazolines]]




{{nervous-system-drug-stub}}
{{sedative-stub}}

[[fr:Romifidine]]
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