LP-44: Difference between revisions

| routes_of_administration =

| excretion =

| molecular_weight = 451.666 g/mol

'''LP-44''' is a drug which acts as a potent and selective [[agonist]] at the [[5-HT7 receptor|5HT₇]] [[serotonin]] [[Receptor (biochemistry)|receptor]]. While LP-44 is less selective than the related compound [[LP-12]], it has been more widely used in research and has been used to show the complex role of 5-HT₇ receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.<ref name="pmid18466985">{{cite journal |author=Monti JM, Leopoldo M, Jantos H |title=The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat |journal=Behavioural Brain Research |volume=191 |issue=2 |pages=184–9 |year=2008 |month=August |pmid=18466985 |doi=10.1016/j.bbr.2008.03.025 |url=}}</ref><ref name="pmid21371532">{{cite journal |author=Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO |title=Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway |journal=Neuroscience |volume=182 |issue= |pages=71–81 |year=2011 |month=May |pmid=21371532 |doi=10.1016/j.neuroscience.2011.02.042 |url=}}</ref><ref name="pmid21459634">{{cite journal |author=Monti JM |title=Serotonin control of sleep-wake behavior |journal=Sleep Medicine Reviews |volume=15 |issue=4 |pages=269–81 |year=2011 |month=August |pmid=21459634 |doi=10.1016/j.smrv.2010.11.003 |url=}}</ref><ref name="pmid21538661">{{cite journal |author=Costa L, Trovato C, Musumeci SA, Catania MV, Ciranna L |title=5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission |journal=Hippocampus |volume= |issue= |pages= |year=2011 |month=April |pmid=21538661 |doi=10.1002/hipo.20940 |url=}}</ref>

[[Category:Serotonin receptor agonists]]