LP-211: Difference between revisions
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{{Short description|Chemical compound}} |
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{{Drugbox |
{{Drugbox |
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| Verifiedfields = changed |
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| verifiedrevid = 449685788 |
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| IUPAC_name = N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide |
| IUPAC_name = N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide |
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| image = LP-211_structure.png |
| image = LP-211_structure.png |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
| legal_status = |
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| routes_of_administration = |
| routes_of_administration = |
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<!--Pharmacokinetic data--> |
<!--Pharmacokinetic data--> |
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| metabolism = |
| metabolism = |
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| elimination_half-life = |
| elimination_half-life = |
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| excretion = |
| excretion = |
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<!--Identifiers--> |
<!--Identifiers--> |
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| CAS_number = |
| CAS_number = 1052147-86-0 |
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| ATC_prefix = |
| ATC_prefix = |
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| ATC_suffix = |
| ATC_suffix = |
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| PubChem = 25107716 |
| PubChem = 25107716 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 23343345 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = NCS2VAH93R |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=30 | H=34 | N=4 | O=1 |
| C=30 | H=34 | N=4 | O=1 |
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| molecular_weight = 466.616 g/mol |
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| smiles = N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4 |
| smiles = N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4 |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35) |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = BQEDZLDNNBDKDS-UHFFFAOYSA-N |
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}} |
}} |
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'''LP-211''' is a drug which acts as a potent and selective [[agonist]] at the [[5-HT7 receptor|5HT<sub>7</sub>]] [[serotonin |
'''LP-211''' is a drug which acts as a potent and selective [[agonist]] at the [[5-HT7 receptor|5HT<sub>7</sub>]] [[serotonin receptor]], with better brain penetration than older 5-HT<sub>7</sub> agonists in the same series, and similar effects in animals.<ref name="pmid20600619">{{cite journal |vauthors=Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R |title=LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor |journal=Neuroscience Letters |volume=481 |issue=1 |pages=12–6 |date=August 2010 |pmid=20600619 |pmc=2910240 |doi=10.1016/j.neulet.2010.06.036 }}</ref><ref name="pmid21459634">{{cite journal |author=Monti JM |title=Serotonin control of sleep-wake behavior |journal=Sleep Medicine Reviews |volume=15 |issue=4 |pages=269–81 |date=August 2011 |pmid=21459634 |doi=10.1016/j.smrv.2010.11.003 }}</ref> |
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==See also== |
==See also== |
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==References== |
==References== |
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{{ |
{{Reflist}} |
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{{Serotonin receptor modulators}} |
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{{Serotonergics}} |
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{{Piperazines}} |
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[[Category: |
[[Category:5-HT7 agonists]] |
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[[Category:Piperazines]] |
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