FGIN-143: Difference between revisions

| verifiedrevid = 424754979

| molecular_weight = 487.503 [[gram|g]]/[[mole (unit)|mol]]

| smiles = c3cc(Cl)ccc3-c2nc1ccc(Cl)cc1c2CC(=O)N(CCCCCC)CCCCCC

'''FGIN-1-43''' is an [[anxiolytic]] drug which acts as a selective [[agonist]] at the [[TSPO (protein)|peripheral benzodiazepine receptor]], also known as the mitochondrial 18 kDa translocator protein or TSPO. It is thought to produce anxiolytic effects by stimulating [[steroidogenesis]] of [[neuroactive steroid]]s such as [[allopregnanolone]], and is several times more potent than the related drug [[FGIN-127]].<ref name="pmid1326631">{{cite journal |title=2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR) |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=262 |issue=3 |pages=971–8 |year=1992 |month=September |pmid=1326631 |doi= |url= |author1=Romeo E |author2=Auta J |author3=Kozikowski AP |author4=Ma D |author5=Papadopoulos V |author6=Puia G |author7=Costa E |author8=Guidotti A |author-separator=,}}</ref><ref name="pmid8411007">{{cite journal |title=Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands |journal=Journal of Medicinal Chemistry |volume=36 |issue=20 |pages=2908–20 |year=1993 |month=October |pmid=8411007 |doi= 10.1021/jm00072a010|url= |author1=Kozikowski AP |author2=Ma D |author3=Brewer J |author4=Sun S |author5=Costa E |author6=Romeo E |author7=Guidotti A |author-separator=,}}</ref><ref name="pmid8043504">{{cite journal |title=The pharmacology of neurosteroidogenesis |journal=The Journal of Steroid Biochemistry and Molecular Biology |volume=49 |issue=4-6 |pages=385–9 |year=1994 |month=June |pmid=8043504 |doi= 10.1016/0960-0760(94)90284-4|url= |author1=Costa E |author2=Auta J |author3=Guidotti A |author4=Korneyev A |author5=Romeo E |author-separator=,}}</ref><ref name="pmid11732760">{{cite journal |title=Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43 |journal=The Journal of Pharmacy and Pharmacology |volume=53 |issue=11 |pages=1561–8 |year=2001 |month=November |pmid=11732760 |doi= 10.1211/0022357011777945|url= |author1=Guillon J |author2=Boulouard M |author3=Lelong V |author4=Dallemagne P |author5=Rault S |author6=Jarry C |author-separator=,}}</ref>

[[Category:Organochlorides]]

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