SB-215505: Difference between revisions

| verifiedrevid = 449561713

| image = SB-215,505_structure.png

| width = 220

| molecular_weight = 337.803 g/mol

'''SB-215,505''' is a drug which acts as a potent and selective [[Antagonist (pharmacology)|antagonist]] at the [[serotonin]] [[5-HT2B receptor|5-HT_2B]] [[Receptor (biochemistry)|receptor]], with good selectivity over the related [[5-HT2A receptor|5-HT_2A]] and [[5-HT2C receptor|5-HT_2C]] receptors.<ref name="pmid15265808">{{cite journal |author=Kantor S, Jakus R, Balogh B, Benko A, Bagdy G |title=Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505 |journal=British Journal of Pharmacology |volume=142 |issue=8 |pages=1332–42 |year=2004 |month=August |pmid=15265808 |pmc=1575194 |doi=10.1038/sj.bjp.0705887 |url=}}</ref> It is used in scientific research into the function of the 5-HT₂ family of receptors, especially to study the role of 5-HT_2B receptors in the heart,<ref name="pmid15302781">{{cite journal |author=Jaffré F, Callebert J, Sarre A, Etienne N, Nebigil CG, Launay JM, Maroteaux L, Monassier L |title=Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts |journal=Circulation |volume=110 |issue=8 |pages=969–74 |year=2004 |month=August |pmid=15302781 |doi=10.1161/01.CIR.0000139856.20505.57 |url=}}</ref><ref name="pmid16962085">{{cite journal |author=Liang YJ, Lai LP, Wang BW, Juang SJ, Chang CM, Leu JG, Shyu KG |title=Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-kappaB in cardiomyocytes |journal=Cardiovascular Research |volume=72 |issue=2 |pages=303–12 |year=2006 |month=November |pmid=16962085 |doi=10.1016/j.cardiores.2006.08.003 |url=}}</ref><ref name="pmid18591460">{{cite journal |author=Monassier L, Laplante MA, Jaffré F, Bousquet P, Maroteaux L, de Champlain J |title=Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice |journal=Hypertension |volume=52 |issue=2 |pages=301–7 |year=2008 |month=August |pmid=18591460 |doi=10.1161/HYPERTENSIONAHA.107.105551 |url=}}</ref> and to distinguish 5-HT_2B-mediated responses from those produced by 5-HT_2A or 5-HT_2C.<ref name="pmid10188965">{{cite journal |author=Reavill C, Kettle A, Holland V, Riley G, Blackburn TP |title=Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist |journal=British Journal of Pharmacology |volume=126 |issue=3 |pages=572–4 |year=1999 |month=February |pmid=10188965 |pmc=1565856 |doi=10.1038/sj.bjp.0702350 |url=}}</ref><ref name="pmid12377394">{{cite journal |author=Fletcher PJ, Grottick AJ, Higgins GA |title=Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding |journal=Neuropsychopharmacology |volume=27 |issue=4 |pages=576–86 |year=2002 |month=October |pmid=12377394 |doi=10.1016/S0893-133X(02)00342-1 |url=}}</ref><ref name="pmid17673981">{{cite journal |author=Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA |title=Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test |journal=Psychopharmacology |volume=195 |issue=2 |pages=223–34 |year=2007 |month=December |pmid=17673981 |doi=10.1007/s00213-007-0891-z |url=}}</ref>

== References ==

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[[Category:Organochlorides]]

[[Category:Indoles]]

[[Category:Amides]]