6-Fluoro-DMT: Difference between revisions

{{Orphan|date=April 2011}}

| verifiedrevid = 449579076

| InChI = 1/C12H15FN2/c1-15(2)6-5-9-8-14-12-7-10(13)3-4-11(9)12/h3-4,7-8,14H,5-6H2,1-2H3

| InChIKey = DZXZPVGWRZCXDH-UHFFFAOYAC

| CAS_number =

| PubChem = 2762738

| molecular_weight = 206.26 g/mol

| smiles = CN(C)CCC1=CNC2=C1C=C(C=C2)F

6-Fluoro-DMT possess [[affinity (pharmacology)|affinity]] for the [[5-HT1A|5-HT_1A]] (392.6 nM), [[5-HT1B|5-HT_1B]] (217.7 nM), [[5-HT1D|5-HT_1D]] (55.4 nM), [[5-HT1E|5-HT_1E]] (460.8 nM), [[5-HT2A|5-HT_2A]] (866 nM), [[5-HT2B|5-HT_2B]] (29.8 nM), [[5-HT2C|5-HT_2C]] (674.2 nM), [[5-HT5A|5-HT_5A]] (960.5 nM), [[5-HT6|5-HT₆]] (25.6 nM), [[5-HT7|5-HT₇]] (40.8 nM), [[D1 receptor|D₁]] (547.3 nM), [[D2 receptor|D₂]] (610.4 nM), [[D3 receptor|D₃]] (866.8 nM), [[D4 receptor|D₄]] (1,454 nM), [[D5 receptor|D₅]] (6,291 nM), [[α1A-adrenergic|α_1A-adrenergic]] (173.3 nM), [[α2B-adrenergic|α_2B-adrenergic]] (295.5 nM), [[α2C-adrenergic|α_2C-adrenergic]] (148.8 nM), [[H1 receptor|H₁]] (46.6 nM), [[H2 receptor|H₂]] (925.4 nM), [[Imidazoline-1 receptor|I₁]] (898.4 nM), [[Sigma-1 receptor|₁]] (6,892 nM), and [[Sigma-2 receptor|₂]] (7,128 nM) [[receptor (biochemistry)|receptor]]s, as well as the [[serotonin transporter|SERT]] (144.6 nM).<ref name="pmid20126400">{{cite journal | author = Ray TS | title = Psychedelics and the human receptorome |journal = Plos One | volume = 5 | issue = 2 | pages = e9019 | year = 2010 | pmid = 20126400 | doi = 10.1371/journal.pone.0009019 | url = | pmc=2814854}}</ref> It has low/negligible (> 10,000 nM) affinity for the [[5-HT3|5-HT₃]], [[α1B-adrenergic|α_1B-adrenergic]], [[α2A-adrenergic|α_2A-adrenergic]], [[β1-adrenergic|β₁-adrenergic]], [[β2-adrenergic|β₂-adrenergic]], [[H3 receptor|H₃]], [[H4 receptor|H₄]], and [[Muscarinic acetylcholine receptor M1|M₁]]-[[Muscarinic acetylcholine receptor M5|M₅]] receptors, as well as the [[dopamine transporter|DAT]] and [[norepinephrine transporter|NET]].<ref name="pmid20126400"/> It has not been screened at [[5-HT1F|5-HT_1F]], [[5-HT4|5-HT₄]], [[α1D-adrenergic|α_1D-adrenergic]], [[β3-adrenergic|β₃-adrenergic]], or [[vesicular monoamine transporter 1|VMAT₁]]/[[vesicular monoamine transporter 2|VMAT₂]].

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