Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Meptazinol: Difference between pages
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Saving copy of the {{drugbox}} taken from revid 457279625 of page Meptazinol for the Chem/Drugbox validation project (updated: 'CAS_number'). |
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{{Short description|Opioid analgesic drug}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:Meptazinol|oldid=457279625}} 457279625] of page [[Meptazinol]] with values updated to verified values.}} |
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{{Drugbox |
{{Drugbox |
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| Verifiedfields = changed |
| Verifiedfields = changed |
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| Watchedfields = changed |
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| verifiedrevid = |
| verifiedrevid = 462248630 |
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| IUPAC_name = (''RS'')-3-(3- |
| IUPAC_name = (''RS'')-3-(3-Ethyl-1-methylazepan-3-yl)phenol |
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| image = Meptazinol Enantiomers Structural Formulae.png |
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| image = Meptazinol.svg |
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| width = 150 |
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| chirality = [[Racemic mixture]] |
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| width2 = |
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| imagename = 1 : 1 mixture (racemate) |
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| drug_name = Meptazinol |
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<!--Clinical data--> |
<!--Clinical data--> |
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| tradename = |
| tradename = Meptid |
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| Drugs.com = {{drugs.com|international|meptazinol}} |
| Drugs.com = {{drugs.com|international|meptazinol}} |
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| licence_EU = <!-- EMEA requires brand name --> |
| licence_EU = <!-- EMEA requires brand name --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
| pregnancy_category = |
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| legal_AU = Schedule 4 |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = POM |
| legal_UK = POM |
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| bioavailability = |
| bioavailability = |
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| protein_bound = |
| protein_bound = |
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| metabolism = The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours |
| metabolism = The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours |
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| elimination_half-life = Half- |
| elimination_half-life = Half-life (1.4–4 hours) |
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| excretion = The drug is rapidly |
| excretion = The drug is rapidly metabolized to the [[glucuronide]], and mostly excreted in the urine |
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<!--Identifiers--> |
<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct| |
| index2_label = HCl |
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| CAS_number_Ref = {{cascite|correct|CAS}} |
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| CAS_number = |
| CAS_number = 54340-58-8 |
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| CAS_number2_Ref = {{cascite|correct|CAS}} |
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| CAS_number2 = 59263-76-2 |
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| ⚫ | |||
| UNII2_Ref = {{fdacite|correct|FDA}} |
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| UNII2 = T62FQ4ZCPA |
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| ATC_prefix = N02 |
| ATC_prefix = N02 |
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| ATC_suffix = AX05 |
| ATC_suffix = AX05 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 37469 |
| ChemSpiderID = 37469 |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D08182 |
| KEGG = D08182 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| chemical_formula = |
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| C=15 | H=23 | N=1 | O=1 |
| C=15 | H=23 | N=1 | O=1 |
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| molecular_weight = 233.34922 g/mol |
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| InChI = 1/C15H23NO/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13/h6-8,11,17H,3-5,9-10,12H2,1-2H3 |
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| InChIKey = JLICHNCFTLFZJN-UHFFFAOYAS |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C15H23NO/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13/h6-8,11,17H,3-5,9-10,12H2,1-2H3 |
| StdInChI = 1S/C15H23NO/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13/h6-8,11,17H,3-5,9-10,12H2,1-2H3 |
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| sec_combustion = |
| sec_combustion = |
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}} |
}} |
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'''Meptazinol''' (trade name '''Meptid''') is an [[opioid]] [[analgesic]] developed by [[Wyeth]] in the 1970s.<ref>{{ cite patent | country = US | status = patent | number = 4197239 | title = Hexahydroazepine, Piperidine and Pyrrolidine Derivatives | gdate = 1980-04-08 | inventor = Cavalla JF, Shepherd RG, White AC | assign1 = Wyeth }}</ref> Indications for use in moderate to severe [[pain]], most commonly used to treat pain in [[obstetrics]] ([[childbirth]]). |
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Meptazinol is a 3-phenylazepane derivative, whereas the other phenazepanes like [[ethoheptazine]] and [[proheptazine]] are [[4-phenylazepane]]s. |
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A partial [[mu opioid receptor|μ-opioid receptor]] [[agonist]], its mixed [[agonist]]/[[Receptor antagonist|antagonist]] activity affords it a lower risk of [[physical dependence|dependence]] and [[drug abuse|abuse]] than full μ [[agonist]]s like [[morphine]]. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other [[opioid]]s such as [[morphine]], [[pentazocine]], or [[buprenorphine]].<ref name="Holmes 1985">{{ cite journal |vauthors=Holmes B, Ward A | title = Meptazinol. A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy | journal = Drugs | year = 1985 | volume = 30 | issue = 4 | pages = 285–312 | pmid = 2998723 | doi=10.2165/00003495-198530040-00001| s2cid = 208818234 }}</ref> |
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==References== |
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{{Reflist|30em}} |
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==External links== |
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* {{MeshName|Meptazinol}} |
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{{Analgesics}} |
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{{Opioidergics}} |
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[[Category:Synthetic opioids]] |
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[[Category:Azepanes]] |
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[[Category:Phenols]] |
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{{analgesic-stub}} |
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