Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Norfenefrine: Difference between pages

{{Short description|Sympathomimetic drug}}

{{Infobox drug

| verifiedrevid = 462263073

| IUPAC_name = 3-(2-Amino-1-hydroxyethyl)phenol

| image2 = (R)-Norfenefrine molecule ball.png

| alt2 = Ball-and-stick model of (R)-Norfenefrine

| pregnancy_category =

| legal_status = Rx-only

| routes_of_administration =

| metabolism = ''m''-hydroxymandelic acid<ref name="pmid4277715">{{cite journal | vauthors = Hengstmann JH, Konen W, Konen C, Eichelbaum M, Dengler HJ | title = The physiological disposition of p-octopamine in man | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | volume = 283 | issue = 1 | pages = 93–106 | year = 1974 | pmid = 4277715 | doi = 10.1007/bf00500148 | s2cid = 35523412 }}</ref><ref>{{cite journal | vauthors = D'Andrea G, Nordera G, Pizzolato G, Bolner A, Colavito D, Flaibani R, Leon A | title = Trace amine metabolism in Parkinson's disease: low circulating levels of octopamine in early disease stages | journal = Neuroscience Letters | volume = 469 | issue = 3 | pages = 348–351 | date = January 2010 | pmid = 20026245 | doi = 10.1016/j.neulet.2009.12.025 | s2cid = 12797090 }}</ref>

| excretion =

| CAS_number_Ref = {{cascite|changed|??}}

| CAS_number = 536-21-0

| CAS_supplemental = <br />15308-34-6 ([[hydrochloride]])

| UNII_Ref = {{fdacite|correct|FDA}}

| C = 8 | H = 11 | N = 1 | O = 2

| synonyms = Norfenephrine<br />Norphenephrine<br />Norphenylephrine<br />''meta''-Norsynephrine<br />''meta''-Octopamine<br />3-Octopamine

'''Norfenefrine''' ([[International Nonproprietary Name|INN]]; also known as '''''meta''-octopamine''', '''3-octopamine''', and '''3,β-dihydroxyphenethylamine''') is an [[adrenergic]] [[drug|agent]] used as a [[sympathomimetic]] [[drug]] which is marketed in [[Europe]], [[Japan]], and [[Mexico]].<ref name="Macdonald1997">{{cite book | author = Macdonald F | title = Dictionary of Pharmacological Agents | url = https://books.google.com/books?id=DeX7jgInYFMC&pg=PA104 | access-date = 24 April 2012 | year = 1997 | publisher = CRC Press | isbn = 978-0-412-46630-4 | page = 104 }}</ref><ref name="Index Nominum 2000: International Drug Directory">{{cite book | title = Index Nominum 2000: International Drug Directory | url = https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA750 | access-date = 24 April 2012 | year = 2000 | publisher = Taylor & Francis | isbn = 978-3-88763-075-1 | page = 750 }}</ref> Along with its [[structural isomer]] [[Octopamine|''p''-octopamine]] and the [[tyramine]]s, norfenefrine is a [[natural product|naturally occurring]], [[endogenous]] [[trace amine]] and plays a role as a minor [[neurotransmitter]] in the [[brain]].<ref name="pmid340613">{{cite journal | vauthors = Danielson TJ, Boulton AA, Robertson HA | title = m-Octopamine, p-octopamine and phenylethanolamine in rat brain: a sensitive, specific assay and the effects of some drugs | journal = Journal of Neurochemistry | volume = 29 | issue = 6 | pages = 1131–1135 | date = December 1977 | pmid = 340613 | doi = 10.1111/j.1471-4159.1977.tb06519.x | s2cid = 26137006 }}</ref>

Some brand names for it include Coritat, Energona, Hypolind, and Novadral.

== See also ==

* [[meta-Tyramine|''m''-Tyramine]]

* [[Phenylephrine]]

* [[Metaraminol]]

* [[Ciclafrine]]

== References ==

{{Reflist}}

{{Cardiac stimulants excluding cardiac glycosides}}

{{Neurotransmitters}}

{{Adrenergic receptor modulators}}

{{TAAR ligands}}

{{Phenethylamines}}

[[Category:Alpha-adrenergic agonists]]

[[Category:Cardiac stimulants]]

[[Category:Norepinephrine-dopamine releasing agents]]

[[Category:Neurotransmitters]]

[[Category:Phenols]]

[[Category:Phenylethanolamines]]

[[Category:TAAR1 agonists]]

[[Category:Trace amines]]

{{nervous-system-drug-stub}}