Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Pyronaridine: Difference between pages
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Saving copy of the {{drugbox}} taken from revid 456808826 of page Pyronaridine for the Chem/Drugbox validation project (updated: 'CAS_number'). |
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{{Short description|Chemical compound}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:Pyronaridine|oldid=456808826}} 456808826] of page [[Pyronaridine]] with values updated to verified values.}} |
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{{Drugbox |
{{Drugbox |
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| Watchedfields = changed |
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| verifiedrevid = |
| verifiedrevid = 464377675 |
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| IUPAC_name = 4-[(7- |
| IUPAC_name = 4-[(7-Chloro-2-methoxy-pyrido[3,2-b]quinolin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol |
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| image = Pyronaridine.svg |
| image = Pyronaridine.svg |
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<!--Clinical data--> |
<!--Clinical data-->| alt = A chemical diagram of a Pyronaridine molecule |
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| synonyms = Pyronaridine tetraphosphate |
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| tradename = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
| tradename = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
| pregnancy_category = |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = CLP (EU): Acute Tox. 3(H301), Eye Dam. 1 (H318), Repr. 2 (H361), Aquatic Chronic 4 (H413){{clarify|date=February 2017}} |
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| legal_status = |
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| routes_of_administration = Oral, [[intramuscular injection |
| routes_of_administration = Oral, [[intramuscular injection]], [[intravenous therapy]] |
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<!--Pharmacokinetic data--> |
<!--Pharmacokinetic data-->| bioavailability = |
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| excretion = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| H = 32 |
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| Cl = 1 |
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| N = 5 |
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| O = 2 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| C=29 | H=32 | Cl=1 | N=5 | O=2 |
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| molecular_weight = 518.05 g/mol |
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| InChI = 1/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32) |
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| InChIKey = DJUFPMUQJKWIJB-UHFFFAOYAM |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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'''Pyronaridine''' is an [[antimalarial drug]].<ref>{{cite journal | vauthors = Croft SL, Duparc S, Arbe-Barnes SJ, Craft JC, Shin CS, Fleckenstein L, Borghini-Fuhrer I, Rim HJ | display-authors = 6 | title = Review of pyronaridine anti-malarial properties and product characteristics | journal = Malaria Journal | volume = 11 | pages = 270 | date = August 2012 | pmid = 22877082 | pmc = 3483207 | doi = 10.1186/1475-2875-11-270 | doi-access = free }}</ref> It was first made in 1970 and has been in clinical use in China since the 1980s.<ref>{{cite journal | vauthors = Chang C, Lin-Hua T, Jantanavivat C | title = Studies on a new antimalarial compound: pyronaridine | journal = Transactions of the Royal Society of Tropical Medicine and Hygiene | volume = 86 | issue = 1 | pages = 7–10 | year = 1992 | pmid = 1566313 | doi = 10.1016/0035-9203(92)90414-8 }}</ref> |
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In a small (n=88) malaria study in Camaroon, pyronaridine had a 100% cure rate, compared with 60% for [[chloroquine]].<ref>{{cite journal | vauthors = Ringwald P, Bickii J, Basco LK | title = Efficacy of oral pyronaridine for the treatment of acute uncomplicated falciparum malaria in African children | journal = Clinical Infectious Diseases | volume = 26 | issue = 4 | pages = 946–953 | date = April 1998 | pmid = 9564481 | doi = 10.1086/513942 | doi-access = free }}</ref> |
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It is one of the components of the [[artemisinin combination therapy]] [[pyronaridine/artesunate]] (Pyramax).<ref>{{Cite web | url = https://www.ema.europa.eu/documents/medicine-outside-eu/pyramax-summary-public_en.pdf | title = Pyramax | publisher = European Medicines Agency | date = 2016}}</ref> |
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It has also been studied as a potential anticancer drug,<ref>{{cite journal | vauthors = Villanueva PJ, Martinez A, Baca ST, DeJesus RE, Larragoity M, Contreras L, Gutierrez DA, Varela-Ramirez A, Aguilera RJ | display-authors = 6 | title = Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis | journal = PLOS ONE | volume = 13 | issue = 11 | pages = e0206467 | year = 2018 | pmid = 30395606 | pmc = 6218039 | doi = 10.1371/journal.pone.0206467 | doi-access = free | bibcode = 2018PLoSO..1306467V }}</ref> and treatment for Ebola. The combination of pyronaridine and artesunate has been evaluated to have a synergistic effect of stronger antiviral effect and less toxicity.<ref>{{cite journal | vauthors = Lane TR, Massey C, Comer JE, Anantpadma M, Freundlich JS, Davey RA, Madrid PB, Ekins S | display-authors = 6 | title = Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection | journal = PLOS Neglected Tropical Diseases | volume = 13 | issue = 11 | pages = e0007890 | date = November 2019 | pmid = 31751347 | pmc = 6894882 | doi = 10.1371/journal.pntd.0007890 | doi-access = free }}</ref> The combination of pyronaridine and artesunate is being studied as a possible treatment for moderate to severe SARS-COV-2.<ref>{{cite journal | vauthors = Krishna S, Augustin Y, Wang J, Xu C, Staines HM, Platteeuw H, Kamarulzaman A, Sall A, Kremsner P | display-authors = 6 | title = Repurposing Antimalarials to Tackle the COVID-19 Pandemic | journal = Trends in Parasitology | volume = 37 | issue = 1 | pages = 8–11 | date = January 2021 | pmid = 33153922 | pmc = 7572038 | doi = 10.1016/j.pt.2020.10.003 | author-link = Sanjeev Krishna }}</ref> |
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== References == |
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{{Reflist}} |
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{{Antimalarials}} |
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[[Category:Antimalarial agents]] |
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[[Category:Chinese discoveries]] |
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{{antiinfective-drug-stub}} |