Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and Zipeprol: Difference between pages
(Difference between pages)
Content deleted Content added
Saving copy of the {{drugbox}} taken from revid 454697621 of page Zipeprol for the Chem/Drugbox validation project (updated: 'CAS_number'). |
Added the cs1 style template to denote Vancouver ("vanc") citation style, because references contain "vauthors" attribute to specify the list of authors. Added s2cid. | Use this tool. Report bugs. | #UCB_Gadget |
||
| Line 1: | Line 1: | ||
{{Short description|Cough suppressant drug}} |
|||
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:Zipeprol|oldid=454697621}} 454697621] of page [[Zipeprol]] with values updated to verified values.}} |
|||
{{cs1 config|name-list-style=vanc}} |
|||
{{Drugbox |
{{Drugbox |
||
| Verifiedfields = changed |
|||
| verifiedrevid = |
| verifiedrevid = 470637387 |
||
| IUPAC_name = 1-methoxy- 3-[4-(2-methoxy- 2-phenylethyl)piperazin- 1-yl]- 1-phenylpropan- 2-ol |
| IUPAC_name = 1-methoxy- 3-[4-(2-methoxy- 2-phenylethyl)piperazin- 1-yl]- 1-phenylpropan- 2-ol |
||
| image = zipeprol.png |
| image = zipeprol.png |
||
| Line 8: | Line 10: | ||
| tradename = |
| tradename = |
||
| Drugs.com = {{drugs.com|international|zipeprol}} |
| Drugs.com = {{drugs.com|international|zipeprol}} |
||
| pregnancy_AU = <!-- A |
| pregnancy_AU = <!-- A, B1, B2, B3, C, D, X --> |
||
| pregnancy_US = <!-- A |
| pregnancy_US = <!-- A, B, C, D, X --> |
||
| pregnancy_category = |
| pregnancy_category = |
||
| legal_AU = <!-- Unscheduled |
| legal_AU = <!-- Unscheduled, S2, S3, S4, S5, S6, S7, S8, S9 --> |
||
| legal_BR = F2 |
|||
| ⚫ | |||
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-07-24 |title=RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451 |url-status=live |archive-url=https://web.archive.org/web/20230827163149/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451 |archive-date=2023-08-27 |access-date=2023-08-27 |publisher=[[Diário Oficial da União]] |language=pt-BR |publication-date=2023-07-25}}</ref> |
|||
| ⚫ | |||
| legal_DE = Anlage II |
|||
| legal_US = Schedule I <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
|||
| |
| legal_CA = Schedule III |
||
| ⚫ | |||
| ⚫ | |||
| legal_UN = P II |
|||
| routes_of_administration = Oral |
| routes_of_administration = Oral |
||
| Line 23: | Line 28: | ||
| metabolism = |
| metabolism = |
||
| elimination_half-life = |
| elimination_half-life = |
||
| excretion = |
| excretion = |
||
<!--Identifiers--> |
<!--Identifiers--> |
||
| CAS_number_Ref = {{cascite|changed|??}} |
|||
| CAS_number = |
| CAS_number = 34758-83-3 |
||
| ATC_prefix = R05 |
| ATC_prefix = R05 |
||
| ATC_suffix = DB15 |
| ATC_suffix = DB15 |
||
| Line 41: | Line 47: | ||
<!--Chemical data--> |
<!--Chemical data--> |
||
| C=23 | H=32 | N=2 | O=3 |
| C=23 | H=32 | N=2 | O=3 |
||
| molecular_weight = 384.512 g/mol |
|||
| smiles = OC(CN1CCN(CC1)CC(OC)c2ccccc2)C(OC)c3ccccc3 |
| smiles = OC(CN1CCN(CC1)CC(OC)c2ccccc2)C(OC)c3ccccc3 |
||
| InChI = 1/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3 |
|||
| InChIKey = VSTNNAYSCJQCQI-UHFFFAOYAC |
|||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
||
| StdInChI = 1S/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3 |
| StdInChI = 1S/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3 |
||
| Line 50: | Line 53: | ||
| StdInChIKey = VSTNNAYSCJQCQI-UHFFFAOYSA-N |
| StdInChIKey = VSTNNAYSCJQCQI-UHFFFAOYSA-N |
||
}} |
}} |
||
'''Zipeprol''' is a centrally acting [[cough suppressant]] developed in France in the 1970s.<ref>Patent {{cite patent| country=US | number=3718650 | pridate= 1970-03-02 | gdate=1973-02-27 | inventor = Mauvernay RY | title = New Derivatives of Substituted Piperazines}}</ref> It is not a [[morphinan]] derivative (in contrast to [[codeine]] and [[dextromethorphan]]). Zipeprol acts as a local anaesthetic and has [[mucolytic]], [[antihistamine]] and [[anticholinergic]] properties.<ref>{{cite journal | vauthors = Rispat G, Burgi H, Cosnier D, Duchêne-Marullaz P, Streichenberger G | title = General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity | journal = Arzneimittel-Forschung | volume = 26 | issue = 4 | pages = 523–30 | date = April 1976 | pmid = 8057 }}</ref> It is sold with several brand names such as '''Zinolta''' and '''Respilene'''. It is not available in the United States or Canada and has been discontinued in Europe. It is still available in some countries in Asia and South America. |
|||
Zipeprol has been misused in Korea, mainly for the hallucinations it produces. Such use has become an issue due to the seizures and various neurological side effects it causes at high dosages.<ref>{{cite journal | vauthors = Chung H, Park M, Hahn E, Choi H, Choi H, Lim M | title = Recent trends of drug abuse and drug-associated deaths in Korea | journal = Annals of the New York Academy of Sciences | volume = 1025 | issue = 1 | pages = 458–64 | date = October 2004 | pmid = 15542749 | doi = 10.1196/annals.1316.056 | bibcode = 2004NYASA1025..458C | s2cid = 10987790 }}</ref> |
|||
== References == |
|||
{{reflist}} |
|||
{{Cough and cold preparations}} |
|||
{{Piperazines}} |
|||
[[Category:Antitussives]] |
|||
[[Category:Piperazines]] |
|||
[[Category:Phenylethanolamine ethers]] |
|||
[[Category:Secondary alcohols]] |
|||
{{respiratory-system-drug-stub}} |
|||