Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and 17-Phenylandrostenol: Difference between pages
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Saving copy of the {{drugbox}} taken from revid 470196191 of page 17-Phenylandrostenol for the Chem/Drugbox validation project (updated: 'CAS_number'). |
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{{Short description|Chemical compound}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:17-Phenylandrostenol|oldid=470196191}} 470196191] of page [[17-Phenylandrostenol]] with values updated to verified values.}} |
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{{Drugbox |
{{Drugbox |
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| Verifiedfields = changed |
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| Watchedfields = changed |
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| verifiedrevid = |
| verifiedrevid = 477209277 |
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| IUPAC_name = (3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-17-phenyl- 2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
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| IUPAC_name = (3''R'',5''S'',8''R'',9''S'',10''S'',13''S'',14''S'')-10,13-dimethyl-17-phenyl- 2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1''H''-cyclopenta[''a'']phenanthren-3-ol |
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| image = 17-Phenylandrostenol. |
| image = 17-Phenylandrostenol.svg |
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| width = 200 |
| width = 200 |
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<!--Identifiers--> |
<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|changed|??}} |
| CAS_number_Ref = {{cascite|changed|??}} |
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| CAS_number = |
| CAS_number = 694438-95-4 |
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| ATC_prefix = |
| ATC_prefix = |
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| ATC_suffix = |
| ATC_suffix = |
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| chemical_formula = |
| chemical_formula = |
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| C=25 | H=34 | O=1 |
| C=25 | H=34 | O=1 |
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| molecular_weight = 350.535 g/mol |
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| smiles = C[C@]12CC[C@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CC=CC=C5)C)O |
| smiles = C[C@]12CC[C@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CC=CC=C5)C)O |
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| InChI = 1/C25H34O/c1-24-14-12-19(26)16-18(24)8-9-20-22-11-10-21(17-6-4-3-5-7-17)25(22,2)15-13-23(20)24/h3-7,10,18-20,22-23,26H,8-9,11-16H2,1-2H3/t18-,19+,20-,22-,23-,24-,25+/m0/s1 |
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| InChIKey = SINAMTXBCYKFDL-WBJZGETLBO |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C25H34O/c1-24-14-12-19(26)16-18(24)8-9-20-22-11-10-21(17-6-4-3-5-7-17)25(22,2)15-13-23(20)24/h3-7,10,18-20,22-23,26H,8-9,11-16H2,1-2H3/t18-,19+,20-,22-,23-,24-,25+/m0/s1 |
| StdInChI = 1S/C25H34O/c1-24-14-12-19(26)16-18(24)8-9-20-22-11-10-21(17-6-4-3-5-7-17)25(22,2)15-13-23(20)24/h3-7,10,18-20,22-23,26H,8-9,11-16H2,1-2H3/t18-,19+,20-,22-,23-,24-,25+/m0/s1 |
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| synonyms = (3α,5α)-17-Phenyl-androst-16-en-3-ol |
| synonyms = (3α,5α)-17-Phenyl-androst-16-en-3-ol |
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}} |
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'''17-Phenylandrostenol''' ('''17-PA'''), or '''(3α,5α)-17-phenylandrost-16-en-3-ol''', is a [[steroid]] drug which binds to [[GABAA receptor|GABA<sub>A</sub>]] [[Receptor (biochemistry)|receptors]]. It acts as an [[Antagonist (pharmacology)|antagonist]] against the [[sedative]] effects of [[neuroactive steroid]]s, but has little effect when administered by itself, and does not block the effects of [[benzodiazepine]]s or [[barbiturate]]s.<ref name="pmid15102947">{{cite journal |vauthors=Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF |title=Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors |journal=Molecular Pharmacology |volume=65 |issue=5 |pages=1191–7 |date=May 2004 |pmid=15102947 |doi=10.1124/mol.65.5.1191 }}</ref><ref name="pmid17658511">{{cite journal |vauthors=Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A |title=Antagonism of neurosteroid modulation of native γ-aminobutyric acid receptors by (3α,5α)-17-phenylandrost-16-en-3-ol |journal=European Journal of Pharmacology |volume=572 |issue=2–3 |pages=94–101 |date=October 2007 |pmid=17658511 |pmc=2098702 |doi=10.1016/j.ejphar.2007.06.028 }}</ref> |
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==Chemistry== |
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{{See also|List of neurosteroids}} |
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==See also== |
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* [[Androstenol]] |
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==References== |
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<references/> |
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{{GABAergics}} |
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{{DEFAULTSORT:Phenylandrostenol, 17-}} |
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[[Category:Androstanes]] |
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[[Category:GABAA receptor negative allosteric modulators]] |
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[[Category:Neurosteroids]] |
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{{steroid-stub}} |
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