Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and AM-855: Difference between pages
(Difference between pages)
Content deleted Content added
Saving copy of the {{drugbox}} taken from revid 448103357 of page AM-855 for the Chem/Drugbox validation project (updated: ''). |
Importing Wikidata short description: "Analgesic drug" (Shortdesc helper) |
||
| Line 1: | Line 1: | ||
{{Short description|Analgesic drug}} |
|||
{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid [{{fullurl:AM-855|oldid=448103357}} 448103357] of page [[AM-855]] with values updated to verified values.}} |
|||
{{Drugbox |
{{Drugbox |
||
| verifiedrevid = |
| verifiedrevid = 477235932 |
||
| IUPAC_name = ( |
| IUPAC_name = (4''aR'',12''bR'')-8-hexyl-2,5,5-trimethyl-1,4,4a,8,9,10,11,12b-octahydronaphtho[3,2-c]isochromen-12-ol |
||
| image = AM-855. |
| image = AM-855.svg |
||
| width = 240 |
| width = 240 |
||
| Line 17: | Line 17: | ||
<!--Identifiers--> |
<!--Identifiers--> |
||
| CAS_number = |
| CAS_number = 249888-50-4 |
||
| CAS_number_Ref = {{cascite|correct|CAS}} |
|||
| UNII_Ref = {{fdacite|correct|FDA}} |
|||
| UNII = JA784TPZ1U |
|||
| PubChem = 10091328 |
| PubChem = 10091328 |
||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
||
| Line 26: | Line 29: | ||
<!--Chemical data--> |
<!--Chemical data--> |
||
| C=26 | H=38 | O=2 |
| C=26 | H=38 | O=2 |
||
| molecular_weight = 382.577 g/mol |
|||
| smiles = Oc1c4C2CC(C)=CCC2C(C)(C)Oc4cc3c1CCCC3CCCCCC |
| smiles = Oc1c4C2CC(C)=CCC2C(C)(C)Oc4cc3c1CCCC3CCCCCC |
||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
||
| Line 33: | Line 35: | ||
| StdInChIKey = GAAJNVWIOIOMPO-IPKCRJEZSA-N |
| StdInChIKey = GAAJNVWIOIOMPO-IPKCRJEZSA-N |
||
}} |
}} |
||
'''AM-855''' (part of the [[List of AM cannabinoids|AM cannabinoid series]]) is an [[analgesic]] drug which is a [[cannabinoid]] [[agonist]]. It is a derivative of Δ<sup>8</sup>[[Tetrahydrocannabinol]] with a conformationally restricted side chain which has been bound into a fourth ring fused to the [[aromatic]] A-ring of the cannabinoid skeleton. AM-855 is an agonist at both [[Cannabinoid receptor type 1|CB<sub>1</sub>]] and [[Cannabinoid receptor 2 (macrophage)|CB<sub>2</sub>]] with moderate selectivity for CB<sub>1</sub>, with a [[Dissociation constant|K<sub>i</sub>]] of 22.3 nM at CB<sub>1</sub> and 58.6 nM at CB<sub>2</sub>.<ref>{{cite journal | vauthors = Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A | title = Novel conformationally restricted tetracyclic analogs of Δ<sup>8</sup>-tetrahydrocannabinol | journal = Bioorganic & Medicinal Chemistry Letters | volume = 9 | issue = 15 | pages = 2119–24 | date = August 1999 | pmid = 10465529 | doi = 10.1016/S0960-894X(99)00355-8 | authorlink5 = Alexandros Makriyannis }}</ref> |
|||
==References== |
|||
{{reflist}} |
|||
{{cannabinoids}} |
|||
[[Category:AM cannabinoids]] |
|||
[[Category:Benzochromenes]] |
|||
[[Category:Phenols]] |
|||
{{cannabinoid-stub}} |
|||