Isopropylmalic acid
Appearance
(Redirected from (2S)-2-isopropylmalate)
![]() 2-Isopropylmalic acid
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![]() 3-Isopropylmalic acid
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Names | |
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IUPAC names
3-Isopropylmalic acid
2-Hydroxy-3-isopropylsuccinic acid | |
Other names
Isopropylmalate
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Identifiers | |
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3D model (JSmol)
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ChEBI |
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ChemSpider | |
DrugBank |
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ECHA InfoCard | 100.159.209 |
EC Number |
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PubChem CID
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UNII |
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CompTox Dashboard (EPA)
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Properties | |
C7H12O5 | |
Molar mass | 176.168 g·mol−1 |
Hazards | |
GHS labelling: | |
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Warning | |
H315, H319, H335 | |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Isopropylmalic acid (isopropylmalate) is an intermediate in the biosynthesis of leucine,[1] synthesized from oxoisovalerate by 2-isopropylmalate synthase and converted into isopropyl-3-oxosuccinate by 3-isopropylmalate dehydrogenase. Two isomers are important, the 2- and 3-isopropyl derivatives, and these are interconverted by isopropylmalate dehydratase.
References
[edit]- ^ Strassman, Murray; Ceci, Louis N. (1963). "Enzymatic Formation of α-Isopropylmalic Acid, an Intermediate in Leucine Biosynthesis". Journal of Biological Chemistry. 238 (7): 2445–2452. doi:10.1016/S0021-9258(19)67991-3. PMID 13978769.