The 2005–06 FIBA EuroCup Challenge was the 4th edition of Europe's fourth-tier level transnational competition for men's professional basketball clubs.[1] This season, 24 teams participated. Russian team Ural Great Perm won the title, by beating Khimik in the dounle final.
The quarterfinals were two-legged ties determined on aggregate score. The first legs was played on January 19. All return legs were played on January 26.