3,4-Difluoroamphetamine

3,4-Difluoroamphetamine
Identifiers
	IUPAC name 1-(3-Chlorophenyl)-N-methylpropan-2-amine;
CAS Number	31338-32-6;
PubChem CID	11182888;
ChemSpider	9357973;
CompTox Dashboard (EPA)	DTXSID80457891 ;
Chemical and physical data
Formula	C9H11F2N
Molar mass	171.191 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(CC1=CC(=C(C=C1)F)F)N;
	InChI InChI=1S/C9H11F2N/c1-6(12)4-7-2-3-8(10)9(11)5-7/h2-3,5-6H,4,12H2,1H3; Key:GJEXOPSQWJWJRQ-UHFFFAOYSA-N;

3,4-Difluoroamphetamine (DFA) is a substituted amphetamine which has been sold as a designer drug. It has relatively weak activity as a serotonin releasing agent with only around 1/4 of the affinity for the serotonin transporter compared to MDA, but its activity at other targets has not been studied.^[1]^[2]

References

^ Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL (February 2004). "Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters". The Journal of Pharmacology and Experimental Therapeutics. 308 (2): 679–687. doi:10.1124/jpet.103.057836. PMID 14593087. S2CID 6439942.
^ Walline CC, Nichols DE, Carroll FI, Barker EL (June 2008). "Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition". The Journal of Pharmacology and Experimental Therapeutics. 325 (3): 791–800. doi:10.1124/jpet.108.136200. PMC 2637348. PMID 18354055.

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