3-Deazaneplanocin A

3-Deazaneplanocin A
Identifiers
3D model (JSmol)	Interactive image;
ChemSpider	65874;
ECHA InfoCard	100.224.238
PubChem CID	73087;
CompTox Dashboard (EPA)	DTXSID30144562 ;
	InChI InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1 Key: OMKHWTRUYNAGFG-IEBDPFPHSA-N; InChI=1/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1 Key: OMKHWTRUYNAGFG-IEBDPFPHBD;
	SMILES n3ccc1c(ncn1[C@@H]2/C=C(/CO)[C@@H](O)[C@H]2O)c3N;
Properties
Chemical formula	C12H14N4O3
Molar mass	262.265
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

3-Deazaneplanocin A is a S-adenosylhomocysteine synthesis inhibitor. Studies have shown that it acts as an anti-cancer drug with both colorectal and ovarian tumours.^[1]^[2]

References

^ Glazer, R.I.; Knode,M.C., Tseng, C.K., Haines, D.R., Marquez, V.E. (1986). "3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells". Biochemical Pharmacology. 35 (24). Elsevier. ISSN 0006-2952.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Liang, Shen (2013). "3-Deazaneplanocin A is a Promising Therapeutic Agent for Ovarian Cancer Cells". Asian Pacific Journal of Cancer Prevention. 14 (5). ISSN 1513-7368.