Paraburkholderia xenovorans
| Paraburkholderia xenovorans | |
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| Species: | P. xenovorans
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| Binomial name | |
| Paraburkholderia xenovorans (Goris et al. 2004) Sawana et al. 2015[1]
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Burkholderia xenovorans Goris et al. 2004 | |
Paraburkholderia xenovorans is a species of Proteobacteria.
Genomics
The genome of Paraburkholderia xenovorans (LB400) is one of the largest bacterial genomes completely sequenced to date. The recent genomic studies of this organism have helped expand understanding of bacterial catabolism, noncatabolic physiological adaptation to organic compounds, and the evolution of large bacterial genomes. The metabolic pathways from phylogenetically diverse isolates are very similar with respect to overall organization. As originally noted in pseudomonads, a large number of "peripheral aromatic" pathways funnel a range of natural and xenobiotic compounds into a restricted number of "central aromatic" pathways. These pathways are genetically organized in genus-specific fashions. Comparative genomic studies reveal that some pathways are more widespread than initially thought. Functional genomic studies have established that even organisms harboring high numbers of homologous enzymes seem to contain few examples of true redundancy. Analyses have indicated that recent genetic flux appears to have played a more significant role in the evolution of some large genomes, such as Burkholderia xenovorans LB400, than in others. However, the emerging trend is that the large gene repertoires of potent pollutant degraders such as B. xenovorans LB400 have evolved principally through more ancient processes. That this is true in such phylogenetically diverse species is remarkable and further suggests the ancient origin of this catabolic capacity. Aromatic compounds are among the most recalcitrant of organic pollutants and much interest is seen in using microbial biodegradation to clean up contaminated sites.[2]
References
- ^ "Molecular signatures and phylogenomic analysis of the genus Burkholderia: Proposal for division of this genus into the emended genus Burkholderia containing pathogenic organisms and a new genus Paraburkholderia gen. nov. harboring environmental species". Front. Genet. 5: 429. 2014. doi:10.3389/fgene.2014.00429. PMC 4271702. PMID 25566316.
{{cite journal}}: Unknown parameter|authors=ignored (help)CS1 maint: unflagged free DOI (link) - ^ McLeod MP and Eltis LD (2008). "Genomic Insights Into the Aerobic Pathways for Degradation of Organic Pollutants". Microbial Biodegradation: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-17-2.
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