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Shane Crotty

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Shane Patrick Crotty (born 26 January 1974) is a virologist and professor in the Vaccine Discovery Division at La Jolla Institute for Immunology.[1]

Education and academic posts

Crotty completed B.S. degrees in Biology and Writing from Massachusetts Institute of Technology in 1996.[1] He then completed his Ph.D. in 2001 at the University of California, San Francisco with Raul Andino discovering the mechanism of action of the Hepatitis C drug ribavirin.[2][1]

Crotty went on to a postdoctoral fellowship from 2001 to 2003 with Rafi Ahmed at Emory University Vaccine Center studying immunity to viruses.[1] He joined La Jolla Institute for Immunology (LIAI) in 2003, as well as the department of medicine of University of California, San Diego, in 2004 as an adjunct assistant professor. He became an associate member with tenure at LIAI in 2009,[3] and then a professor with tenure.

Research

Crotty's research has focused on immune responses to viral infections, in particular those driven by vaccines. His lab has done major work on the regulation and proliferation of follicular helper T cells, as well as immunological protection from HIV infection and HIV vaccine delivery strategy.[4] [5] In close collaboration with Alessandro Sette, Crotty published the first detailed analysis [6] of the human immune response to SARS-CoV-2, the virus that causes COVID-19, and later confirmed[7] that the adaptive immune response is lasting.

Major publications

  • Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, Lao C, Crotty S (2011). "ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6". Immunity. 34 (6): 932–946. doi:10.1016/j.immuni.2011.03.023. PMC 3124577. PMID 21636296.
  • Johnston RJ, Poholek AC, Ditoro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S (2009). "Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation". Science. 325 (5943): 1006–1010. Bibcode:2009Sci...325.1006J. doi:10.1126/science.1175870. PMC 2766560. PMID 19608860.
  • Crotty S, Felgner P, Davies H, Glidewell J, Villarreal L, Ahmed R (2003). "Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination". The Journal of Immunology. 171 (10): 4969–4973. doi:10.4049/jimmunol.171.10.4969. PMID 14607890. S2CID 32215286.
  • Crotty S, Cameron CE, Andino R (2001). "RNA virus error catastrophe: Direct molecular test by using ribavirin". Proceedings of the National Academy of Sciences. 98 (12): 6895–6900. Bibcode:2001PNAS...98.6895C. doi:10.1073/pnas.111085598. PMC 34449. PMID 11371613.
  • Crotty S, Maag D, Arnold JJ, Zhong W, Lau JY, Hong Z, Andino R, Cameron CE (2000). "The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen". Nature Medicine. 6 (12): 1375–1379. doi:10.1038/82191. PMID 11100123. S2CID 52870674.

Other publications

Crotty is also the author of a biography of David Baltimore entitled Ahead of the Curve.[8][9] He is the co-editor with Rafi Ahmed of Immune Memory and Vaccines: Great Debates.[10]

References

  1. ^ a b c d "Crotty Lab - Lab Members". La Jolla Institute. Retrieved 11 July 2019.
  2. ^ "Shane Crotty". Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery. Retrieved 11 July 2019.
  3. ^ Crotty, Shane. "Biographical Sketch" (PDF).
  4. ^ "Crotty Lab". La Jolla Institute for Immunology.
  5. ^ "New HIV vaccine strategy 'pumps' the immune system". Science Daily. May 9, 2019.
  6. ^ Grifoni, Alba; Weiskopf, Daniela; Ramirez, Sydney I.; Mateus, Jose; Dan, Jennifer M.; Moderbacher, Carolyn Rydyznski; Rawlings, Stephen A.; Sutherland, Aaron; Premkumar, Lakshmanane; Jadi, Ramesh S.; Marrama, Daniel (June 2020). "Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals". Cell. 181 (7): 1489–1501.e15. doi:10.1016/j.cell.2020.05.015. ISSN 0092-8674. PMC 7237901. PMID 32473127.
  7. ^ Dan, Jennifer M.; Mateus, Jose; Kato, Yu; Hastie, Kathryn M.; Yu, Esther Dawen; Faliti, Caterina E.; Grifoni, Alba; Ramirez, Sydney I.; Haupt, Sonya; Frazier, April; Nakao, Catherine (2021-01-06). "Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection". Science: eabf4063. doi:10.1126/science.abf4063. ISSN 0036-8075.
  8. ^ Didier Trono (July 2001). "Ahead of the Curve: David Baltimore's Life in Science". Nature Medicine. 7 (7): 767. doi:10.1038/89868. S2CID 41609105.
  9. ^ Barbara J. Culliton (2003). "Ahead of the Curve: David Baltimore's Life in Science (review)". Bulletin of the History of Medicine. 77 (2): 474–475. doi:10.1353/bhm.2003.0056. S2CID 71233143.
  10. ^ Shane Crotty; Ahmed, Rafi, eds. (2018). Immune Memory and Vaccines: Great Debates. Cold Spring Harbor Laboratory Press. ISBN 978-1-62182-154-0.
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