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Cytoplasm-to-vacuole targeting

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This is an old revision of this page, as edited by JohnnyBflat (talk | contribs) at 10:50, 14 July 2021 (Adding local short description: "Autophagy-related pathway in yeast", overriding Wikidata description "A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming" (Shortdesc helper)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Cytoplasm-to-vacuole targeting (Cvt) is an autophagy-related pathway in yeast. Under vegetative conditions it delivers hydrolases, such as aminopeptidase 1 (Ape1), to the vacuole.[1][2] This makes the cvt pathway the only known biosynthetic pathway to utilize the machinery of autophagy for operation.[1]

Nomenclature

The abbreviation Cvt comes from the emphasis Cytoplasm vacuole targeting, not from Cytoplasm-to-vacuole targeting.

References

  1. ^ a b Lynch-Day MA, Klionsky DJ (2010). "The Cvt pathway as a model for selective autophagy" (PDF). FEBS Letters. 584 (7): 1359–66. doi:10.1016/j.febslet.2010.02.013. hdl:2027.42/116339. PMC 2843786. PMID 20146925.
  2. ^ Klionsky, Daniel J. (2005-01-01). "The molecular machinery of autophagy: unanswered questions". J Cell Sci. 118 (1): 7–18. doi:10.1242/jcs.01620. ISSN 0021-9533. PMC 1828869. PMID 15615779.


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