Thiazovivin

Thiazovivin
Identifiers
	IUPAC name N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide;
CAS Number	1226056-71-8;
PubChem CID	46209426;
ChemSpider	24597612;
ChEMBL	ChEMBL3184878;
CompTox Dashboard (EPA)	DTXSID00673091 ;
ECHA InfoCard	100.236.307
Chemical and physical data
Formula	C15H13N5OS
Molar mass	311.36 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3;
	InChI InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20); Key:DOBKQCZBPPCLEG-UHFFFAOYSA-N;

Thiazovivin is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase. It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells, which can then be used for a wide variety of applications.^[1]^[2]^[3]^[4]

References

^ Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, et al. (November 2009). "A chemical platform for improved induction of human iPSCs". Nature Methods. 6 (11): 805–8. doi:10.1038/nmeth.1393. PMC 3724527. PMID 19838168.
^ Donai K, Inagaki A, So KH, Kuroda K, Sone H, Kobayashi M, et al. (March 2015). "Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions". Cytotechnology. 67 (2): 191–7. doi:10.1007/s10616-013-9686-8. PMC 4329295. PMID 24682663.
^ Mohseni R, Shoae-Hassani A, Verdi J (May 2015). "Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs". Cell Biology International. 39 (5): 515–8. doi:10.1002/cbin.10411. PMID 25490878. S2CID 24813753.
^ Cheng L, Lei Q, Yin C, Wang HY, Jin K, Xiang M (2017). "Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol". Frontiers in Molecular Neuroscience. 10: 348. doi:10.3389/fnmol.2017.00348. PMC 5670152. PMID 29163026.

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[1] Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, et al. (November 2009). "A chemical platform for improved induction of human iPSCs". Nature Methods. 6 (11): 805–8. doi:10.1038/nmeth.1393. PMC 3724527. PMID 19838168.

[2] Donai K, Inagaki A, So KH, Kuroda K, Sone H, Kobayashi M, et al. (March 2015). "Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions". Cytotechnology. 67 (2): 191–7. doi:10.1007/s10616-013-9686-8. PMC 4329295. PMID 24682663.

[3] Mohseni R, Shoae-Hassani A, Verdi J (May 2015). "Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs". Cell Biology International. 39 (5): 515–8. doi:10.1002/cbin.10411. PMID 25490878. S2CID 24813753.

[4] Cheng L, Lei Q, Yin C, Wang HY, Jin K, Xiang M (2017). "Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol". Frontiers in Molecular Neuroscience. 10: 348. doi:10.3389/fnmol.2017.00348. PMC 5670152. PMID 29163026.

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See also

References