HrrF RNA

HrrF RNA
HrrF RNA
	Predicted secondary structure and sequence conservation of Haemophilus regulatory RNA responsive to iron
Identifiers
Rfam	F02728
Other data
Domain(s)	Bacteria
GO	GO:0045975,GO:0010039
SO	SO:0000370
PDB structures	PDBe

HrrF RNA (Haemophilus regulatory RNA responsive to iron Fe) is a small non-coding RNA involved in iron homeostasis in Haemophilus species. Orthologues exist only among other Pasteurellacae. Iron- regulated sRNAs JA01- JA04 were identified in related Aggregatibacter. It is an analog to PrrF and RyhB RNAs. HrrF is maximally expressed when iron levels are low. Ferric uptake regulator (Fur) binds upstream of the hrrF promoter. HrrF stability is not dependent on the RNA chaperone Hfq. RNA-seq has shown that HrrF targets are mRNAs of genes whose products are involved in molybdate uptake, deoxyribonucleotide synthesis, and amino acid synthesis.^[1]

References

^ Santana EA, Harrison A, Zhang X, Baker BD, Kelly BJ, White P, Liu Y, Munson RS (2014-01-01). "HrrF is the Fur-regulated small RNA in nontypeable Haemophilus influenzae". PLOS ONE. 9 (8): e105644. doi:10.1371/journal.pone.0105644. PMC 4144887. PMID 25157846.

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[1] Santana EA, Harrison A, Zhang X, Baker BD, Kelly BJ, White P, Liu Y, Munson RS (2014-01-01). "HrrF is the Fur-regulated small RNA in nontypeable Haemophilus influenzae". PLOS ONE. 9 (8): e105644. doi:10.1371/journal.pone.0105644. PMC 4144887. PMID 25157846.

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See also

References