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PncA

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PncA is a gene encoding pyrazinamidase in Mycobacterium species.[1] Pyrazinamidase converts the drug pyrazinamide to the active form pyrazinoic acid.[2] There is a strong correlation between mutations in pncA and resistance of M. tuberculosis to pyrazinamide.[3]

See also

References

  1. ^ Scorpio A, Zhang Y (June 1996). "Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus". Nat. Med. 2 (6): 662–7. doi:10.1038/nm0696-662. PMID 8640557. S2CID 8579133.
  2. ^ Whitfield, Michael G.; Soeters, Heidi M.; Warren, Robin M.; York, Talita; Sampson, Samantha L.; Streicher, Elizabeth M.; Helden, Paul D. van; Rie, Annelies van (2015-07-28). "A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis". PLOS ONE. 10 (7): e0133869. Bibcode:2015PLoSO..1033869W. doi:10.1371/journal.pone.0133869. ISSN 1932-6203. PMC 4517823. PMID 26218737.
  3. ^ Juréen, Pontus; Werngren, Jim; Toro, Juan-Carlos; Hoffner, Sven (2016-12-15). "Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis". Antimicrobial Agents and Chemotherapy. 52 (5): 1852–1854. doi:10.1128/AAC.00110-08. ISSN 0066-4804. PMC 2346646. PMID 18316515.


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