TRV734

TRV734
Identifiers
	IUPAC name N-[(5-fluoropyridin-3-yl)methyl]-2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethanamine;
PubChem CID	72695064;
Chemical and physical data
Formula	C22H28FN3O
Molar mass	369.484 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCC2(C1)C[C@](CCO2)(CCNCC3=CC(=CN=C3)F)C4=CC=CC=N4;
	InChI InChI=1S/C22H28FN3O/c23-19-13-18(15-25-16-19)14-24-11-8-21(20-5-1-4-10-26-20)9-12-27-22(17-21)6-2-3-7-22/h1,4-5,10,13,15-16,24H,2-3,6-9,11-12,14,17H2/t21-/m1/s1; Key:CRKVMJHROLSFMV-OAQYLSRUSA-N;

TRV734 is a drug developed by Trevena Inc which acts as a biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It is closely related to oliceridine and has a similar pharmacological profile, but unlike oliceridine which has to be injected, TRV734 is suitable to be administered orally.^[1]

References

^ James IE, Skobieranda F, Soergel DG, Ramos KA, Ruff D, Fossler MJ (February 2020). "A First-in-Human Clinical Study With TRV734, an Orally Bioavailable G-Protein-Biased Ligand at the μ-Opioid Receptor". Clinical Pharmacology in Drug Development. 9 (2): 256–266. doi:10.1002/cpdd.721. PMID 31286645. S2CID 195843184.

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[1] James IE, Skobieranda F, Soergel DG, Ramos KA, Ruff D, Fossler MJ (February 2020). "A First-in-Human Clinical Study With TRV734, an Orally Bioavailable G-Protein-Biased Ligand at the μ-Opioid Receptor". Clinical Pharmacology in Drug Development. 9 (2): 256–266. doi:10.1002/cpdd.721. PMID 31286645. S2CID 195843184.

[1]

See also

References