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Ecdysteroid

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Chemical structure of the ecdysteroid ecdysone

Ecdysteroids are arthropod steroid hormones that are mainly responsible for molting, development and, to a lesser extent, reproduction;[1][2][3] examples of ecdysteroids include ecdysone, ecdysterone, turkesterone and 2-deoxyecdysone.[4] These compounds are synthesized in arthropods from dietary cholesterol upon metabolism by the Halloween family of cytochrome P450s.[5] Phytoecdysteroids also appear in many plants mostly as a protection agents (toxins or antifeedants) against herbivore insects.[6][7]

Ecdysterone has been tested on mammals due to the interest in its potential hypertrophic effect. It has been found to increase hypertrophy in rats at a similar level to some anabolic androgenic steroids and SARM S 1.[8] This is proposed to be through increase of Calcium leading to activation of Akt and protein synthesis in skeletal muscles.[9]

See also

  • Ecdybase, The Ecdysone Handbook - a free online ecdysteroids database

References

  1. ^ de Loof A (2006). "Ecdysteroids: the overlooked sex steroids of insects? Males: the black box". Insect Science. 13 (5): 325–338. doi:10.1111/j.1744-7917.2006.00101.x. S2CID 221810929.
  2. ^ Krishnakumaran A, Schneiderman HA (December 1970). "Control of molting in mandibulate and chelicerate arthropods by ecdysones". The Biological Bulletin. 139 (3): 520–538. doi:10.2307/1540371. JSTOR 1540371. PMID 5494238.
  3. ^ Margam VM, Gelman DB, Palli SR (June 2006). "Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae)". Journal of Insect Physiology. 52 (6): 558–568. doi:10.1016/j.jinsphys.2006.02.003. PMID 16580015.
  4. ^ "Ecdysteroids Information". Examine.com. Retrieved 27 May 2015.
  5. ^ Mykles DL (November 2011). "Ecdysteroid metabolism in crustaceans". The Journal of Steroid Biochemistry and Molecular Biology. 127 (3–5): 196–203. doi:10.1016/j.jsbmb.2010.09.001. PMID 20837145. S2CID 23942645.
  6. ^ Dinan L (June 2001). "Phytoecdysteroids: biological aspects". Phytochemistry. 57 (3): 325–339. doi:10.1016/S0031-9422(01)00078-4. PMID 11393511.
  7. ^ Dinan L, Savchenko T, Whiting P (July 2001). "On the distribution of phytoecdysteroids in plants". Cellular and Molecular Life Sciences. 58 (8): 1121–1132. doi:10.1007/PL00000926. PMID 11529504. S2CID 8496934.
  8. ^ Parr MK, Botrè F, Naß A, Hengevoss J, Diel P, Wolber G (June 2015). "Ecdysteroids: A novel class of anabolic agents?". Biology of Sport. 32 (2): 169–173. doi:10.5604/20831862.1144420. PMC 4447764. PMID 26060342.
  9. ^ Gorelick-Feldman J, Cohick W, Raskin I (October 2010). "Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells". Steroids. 75 (10): 632–637. doi:10.1016/j.steroids.2010.03.008. PMC 3815456. PMID 20363237.


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