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Late embryogenesis abundant proteins

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Late embryogenesis abundant proteins (LEA proteins) are proteins in plants, and some bacteria and invertebrates, that protect against protein aggregation due to desiccation or osmotic stresses associated with low temperature.[1][2][3] LEA proteins were initially discovered accumulating late in embryogenesis of cotton seeds.[4] Although abundant in seeds and pollens, LEA proteins have been found to protect against desiccation, cold, or high salinity in a variety of organisms, including the bacterium Deinococcus radiodurans, nematode Caenorhabditis elegans, Artemia (brine shrimp), and rotifers.[5][6][2]

LEA proteins function by mechanisms which are distinct from those displayed by heat shock molecular chaperones.[1] Although the causes of LEA protein induction have not yet been determined, conformational changes in transcription factors or integral membrane proteins due to water loss have been suggested.[7] LEA proteins are particularly protective of mitochondrial membranes against dehydration damage.[8]

See also

References

  1. ^ a b Goyal, K., Walton, L. J., & Tunnacliffe, A. (2005). "LEA proteins prevent protein aggregation due to water stress". Biochemical Journal. 388 (Part 1): 151–157. doi:10.1042/BJ20041931. PMC 1186703. PMID 15631617.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b Hundertmark M, Hincha DK (2008). "LEA (late embryogenesis abundant) proteins and their encoding genes in Arabidopsis thaliana". BMC Genomics. 9: 118. doi:10.1186/1471-2164-9-118. PMC 2292704. PMID 18318901.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ Liu, Y; Chakrabortee, S; Li, R; Zheng, Y; Tunnacliffe, A (18 February 2011). "Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation". FEBS Letters. 585 (4): 630–4. doi:10.1016/j.febslet.2011.01.020. PMID 21251910. S2CID 23589368.
  4. ^ Dure L 3rd, Greenway SC, Galau GA (1981). "Developmental biochemistry of cottonseed embryogenesis and germination: changing messenger ribonucleic acid populations as shown by in vitro and in vivo protein synthesis". Biochemistry. 20 (14): 4162–4168. doi:10.1021/bi00517a033. PMID 7284317.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
  5. ^ Gal TZ, Glazer I, Koltai H (2004). "An LEA group 3 family member is involved in survival of C. elegans during exposure to stress". FEBS Letters. 577 (1–2): 21–26. doi:10.1016/j.febslet.2004.09.049. PMID 15527756. S2CID 21960486.
  6. ^ Menze MA, Boswell L, Toner M, Hand SC (2009). "Occurrence of mitochondria-targeted Late Embryogenesis Abundant (LEA) gene in animals increases organelle resistance to water stress". Journal of Biological Chemistry. 284 (16): 10714–10719. doi:10.1074/jbc.C900001200. PMC 2667758. PMID 19228698.
  7. ^ Caramelo JJ, Iusem ND (2009). "When cells lose water: Lessons from biophysics and molecular biology". Progress in Biophysics and Molecular Biology. 99 (1): 1–6. doi:10.1016/j.pbiomolbio.2008.10.001. PMID 18977383.
  8. ^ Tolleter D, Hincha DK, Macherel D (2010). "A mitochondrial late embryogenesis abundant protein stabilizes model membranes in the dry state". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798 (10): 1926–1933. doi:10.1016/j.bbamem.2010.06.029. PMID 20637181.


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