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N-nucleotide

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This is an old revision of this page, as edited by Rjwilmsi (talk | contribs) at 17:02, 11 May 2016 (Journal cites: format PMC ref, using AWB (12009)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

N-nucleotides, or nontemplated nucleotides are believed to exist only to create diversity at V(D)J junctions (see V(D)J recombination) during lymphocyte development.[1] The addition of these nucleotides is aided by an enzyme called Terminal deoxynucleotidyl transferase (TdT)

References

  1. ^ Sandor, Z; Calicchio, ML; Sargent, RG; Roth, DB; Wilson, JH (2004). "Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks". Nucleic Acids Res. 32: 1866–73. doi:10.1093/nar/gkh502. PMC 390357. PMID 15047854.
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