Methiodide
In organic chemistry, a methiodide is a chemical derivative produced by the reaction of a compound with methyl iodide. Methiodides may be formed through the methylation of amines:
- R3N + CH3I → (CH3)R3N+I−
Methiodides are generally prepared to alter chemical or pharmacological properties. Examples include:
- Cocaine methiodide, a charged cocaine analog which cannot pass the blood brain barrier and enter the brain[1]
- Bicuculline methiodide, a water-soluble form of bicuculline
References
- ^ Hill ER, Tian J, Tilley MR, Zhu MX, Gu HH (2009). Manzoni OJ (ed.). "Potencies of Cocaine Methiodide on Major Cocaine Targets in Mice". PLoS ONE. 4 (10): e7578. Bibcode:2009PLoSO...4.7578H. doi:10.1371/journal.pone.0007578. PMC 2762027. PMID 19855831.
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