Calx-beta motif
| Calx-beta | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 first ca2+ binding domain of the na,ca-exchanger (ncx1) | |||||||||
| Identifiers | |||||||||
| Symbol | Calx-beta | ||||||||
| Pfam | PF03160 | ||||||||
| InterPro | IPR003644 | ||||||||
| |||||||||
In molecular biology, the calx-beta motif is a protein motif which is present as a tandem repeat in the cytoplasmic domains of Calx sodium-calcium exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif contains a series of beta-strands and turns that form a self-contained beta-sheet.[1][2]
References
- ^ Schwarz EM, Benzer S (September 1997). "Calx, a Na-Ca exchanger gene of Drosophila melanogaster". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10249–54. doi:10.1073/pnas.94.19.10249. PMC 23348. PMID 9294196.
- ^ Schwarz E, Benzer S (July 1999). "The recently reported NIbeta domain is already known as the Calx-beta motif". Trends in Biochemical Sciences. 24 (7): 260. doi:10.1016/S0968-0004(99)01422-X. PMID 10390612.