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Secretagogue

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This is an old revision of this page, as edited by A876 (talk | contribs) at 04:20, 21 September 2018 (split para. link to section with more info about Insulin secretagogues.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

A secretagogue is a substance that causes another substance to be secreted.

One example is gastrin,[1] which stimulates the H/K ATPase in the parietal cells (increased gastric acid production by the stomach). Pentagastrin, a synthetic gastrin, histamine, and acetylcholine are also gastric secretagogues.

Insulin secretagogues, such as sulfonylureas, trigger insulin release by direct action on the KATP channel of the pancreatic beta cells. Blockage of this channel leads to depolarization and secretion of vesicles.

Angiotensin II is a secretagogue for aldosterone from the adrenal gland.

References

  1. ^ Secretagogue at eMedicine Dictionary Archived October 15, 2012, at the Wayback Machine
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