Holdase
In molecular biology, holdases are a particular kind of molecular chaperones that assist the non-covalent folding of proteins in an ATP-independent manner.[1] Examples of holdases are DnaJ and Hsp33.
Holdases bind to protein folding intermediates to prevent their aggregation but without directly refolding them.
References
- ^ Hoffmann, J. R. H.; Linke, K.; Graf, P. C.; Lilie, H.; Jakob, U. (2003). "Identification of a redox-regulated chaperone network". The EMBO Journal. 23 (1): 160–168. doi:10.1038/sj.emboj.7600016. PMC 1271656. PMID 14685279.