Phosphopeptide

Phosphopeptides are modified self antigens which may induce an immune response.

Phosphorylation of serine and threonine residues is conserved during MHC class I and MHC class II antigen processing. Phosphopeptides are thus displayed on the surface of cells. As modified self antigens, they are potentially immunogenic when compared to unmodified self proteins as the immune cells (T-cells) which recognise them are possibly not subject to central tolerance mechanisms. This may contribute to the potential capability of phosophopeptides to serve as tumor antigens in the treatment of colorectal cancer.^[1]

References

^ Penny, S; Abelin, J; Saeed, A; Malaker, S; Trantham, P; Shabanowitz, J; Ward, S; Hunt, D; Cobbold, M (2016). "Phosphopeptides as novel tumour antigens in colorectal cancer". European Journal of Cancer. 61: S213. doi:10.1016/S0959-8049(16)61751-3.

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[1] Penny, S; Abelin, J; Saeed, A; Malaker, S; Trantham, P; Shabanowitz, J; Ward, S; Hunt, D; Cobbold, M (2016). "Phosphopeptides as novel tumour antigens in colorectal cancer". European Journal of Cancer. 61: S213. doi:10.1016/S0959-8049(16)61751-3.

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