Ružička reaction
The Ružička large-ring synthesis or Ružička reaction or Ružička cyclization is an organic reaction in which a dicarboxylic acid is converted to a cyclic ketone at high temperature and a suitable catalyst such as thorium oxide. The reaction is named after Lavoslav Ružička, who invented it in 1926.[1]
The reaction has been applied in the synthesis of Exaltone, a synthetic Muscone.
References
- ^ L. Ruzicka; M. Stoll; H. Schinz (1926). "Zur Kenntnis des Kohlenstoffringes II. Synthese der carbocyclischen Ketone vom Zehner- bis zum Achtzehnerring". Helvetica Chimica Acta. 9 (1): 249–264. doi:10.1002/hlca.19260090130.