Pain wind-up

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This is an old revision of this page, as edited by Sajiky (talk | contribs) at 04:28, 17 March 2019 (Took out the word "perceived". Its insulting and oxymoronic describing someone's pain as "perceived". It insinuates the pain isn't real but, "in your head". I have a rare genetic pain disorder. I had to deal with doctors repeatedly insinuating or just stating, the pain wasn't real but, "in my head". Their ego's preferred to believe that if they can't diagnose it it isn't real. Finally specialist diagnosed Dercum's Disease. One of the most painful conditions there is. "perceived" my ass.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Pain wind-up is the increase in pain intensity over time when a given stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of group C peripheral nerve fibers, leading to progressively increasing electrical response in the corresponding spinal cord (posterior horn) neurons due to priming of the NMDA receptor based response.[1][2] It describes an exponentially progressive increase in firing of WDR neurons with repeated stimulation.

References

  1. ^ Feng Xu; Tianjian Lu (29 May 2011). Introduction to Skin Biothermomechanics and Thermal Pain. Springer. p. 347. ISBN 978-3-642-13201-8. Retrieved 25 April 2012.
  2. ^ Pitcher and Henry (2000). Eur. J. Neurosci., 12:2006–2020.
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