PinT small RNA

PinT sRNA
PinT sRNA
	Predicted secondary structure and sequence conservation of PinT small RNA
Identifiers
Rfam	RF01404
Other data
Domain(s)	Bacteria
SO	SO:0001263
PDB structures	PDBe

In bacteria, PinT small RNA is a small regulatory RNA (sRNA) that is activated during stress and virulence conditions. sRNAs base-pair with target mRNAs and modulate their stability or translation. The expression of PhoP-activated sRNA called PinT is highly induced during Salmonella enterica infection. PinT temporally controls Salmonella virulence genes. On bacterial internalization it controls the expression of invasion associated effectors (SPI-1) through the direct base-pairing with the mRNA. Later in infection it represses the virulence genes (SPI-2) allowing the switch from an invasive state to the state of intracellular replication.^[1]

References

^ Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J (January 2016). "Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions". Nature. 529 (7587): 496–501. doi:10.1038/nature16547. PMID 26789254.

[1] Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J (January 2016). "Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions". Nature. 529 (7587): 496–501. doi:10.1038/nature16547. PMID 26789254.

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