Spitz (protein)
| Spitz | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | ? | ||||||
| Symbol | SPI | ||||||
| Entrez | 35253 | ||||||
| PDB | 3LTF | ||||||
| UniProt | Q01083 | ||||||
| |||||||
Unknown parameter RefSeq
Spitz is a protein in fruit flies which is the major activator of Epidermal Growth Factor Receptor (EGFR).[1]
Function
Spitz is produced as a transmembrane protein in the endoplasmic reticulum. There it associates with a cargo receptor called Star and is trafficked to the Golgi. In the Golgi, Spitz is cleaved by a protease called Rhomboid, which releases Spitz to be trafficked to the cell membrane and released out of the cell.[1] From here it can bind EGFR on the surface of other cells, activating the receptor. Alternatively, Spitz can be bound and inactivated by Argos, inhibiting EGFR activation.[2]
Structure
Spitz is structurally similar to TGF-α.[1]
References
- ^ a b c Shilo BZ (2003). "Signaling by the Drosophila epidermal growth factor receptor pathway during development". Experimental Cell Research. 284 (1): 140–9. doi:10.1016/S0014-4827(02)00094-0. PMID 12648473.
- ^ Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA (2004). "Argos inhibits epidermal growth factor receptor signalling by ligand sequestration". Nature. 430 (7003): 1040–4. doi:10.1038/nature02840. PMID 15329724.